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Association between asthma and cardiovascular diseases: A longitudinal follow

泰然健康网
2025-05-01 03:19

Asthma has been suggested to be a risk factor for cardiovascular diseases (CVDs), although the evidence supporting this relationship is inconclusive. This study aimed to explore the long-term associations between asthma and asthma exacerbations with the occurrence of cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), heart failure (HF), and cerebral stroke, utilizing data from a nationwide cohort. This study utilized data from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015), including information on 111,316 asthma patients and an equal number of 1:1 matched control participants. A propensity score overlap-weighted Cox proportional hazards regression model was used to analyze the overlap-weighted hazard ratios (HRs) of asthma and exacerbated asthma for cardiovascular diseases (CVDs) within this cohort. During the follow-up period, the incidence rate (IR) of IHD per 1000 person-years (PYs) was 7.82 in patients with asthma and 5.79 in controls. The IR of HF was 2.53 in asthmatic patients and 1.36 in controls. After adjustment for covariates, asthmatic patients exhibited 1.27-fold and 1.56-fold higher HRs for IHD (95% confidence interval (CI) = 1.23–1.37, P < 0.001) and HF (95% CI = 1.36–1.63, P < 0.001) than the controls, respectively. In addition, there was an increased HR for IHD and HF in the asthma exacerbation group compared with the nonexacerbated asthma group (adjusted HR, 1.29, 95% CI = 1.24–1.34, P < 0.001 for IHD and aHR 1.68, 95% CI = 1.58–1.79, P < 0.001 for HF). However, the occurrence of stroke was decreased in asthmatic patients compared with controls (aHR = 0.96, 95% CI = 0.93–0.99, P = 0.008). Adults with asthma are more likely to develop CVDs. Additionally, severe asthma exacerbations are significantly associated with an increased occurrence of CVDs.

中文翻译：

哮喘与心血管疾病之间的关联：利用全国健康筛查队列进行的纵向随访研究

哮喘被认为是心血管疾病 (CVD) 的危险因素，尽管支持这种关系的证据尚无定论。本研究旨在利用全国队列数据，探讨哮喘和哮喘恶化与缺血性心脏病 (IHD)、心力衰竭 (HF) 和脑中风等心血管疾病 (CVD) 发生之间的长期关联。本研究利用韩国国民健康保险服务健康筛查队列数据库（2002-2015）的数据，包括 111,316 名哮喘患者和同等数量的 1:1 匹配对照参与者的信息。使用倾向评分重叠加权Cox比例风险回归模型来分析该队列中哮喘和哮喘加重与心血管疾病（CVD）的重叠加权风险比（HR）。在随访期间，哮喘患者每 1000 人年 (PY) 的 IHD 发病率 (IR) 为 7.82，对照组为 5.79。哮喘患者心衰的 IR 为 2.53，对照组为 1.36。调整协变量后，哮喘患者的 IHD（95% 置信区间 (CI) = 1.23–1.37，P < 0.001）和 HF（95% CI = 1.36–1.63，P < 0.001）HR 分别高出 1.27 倍和 1.56 倍）分别比控件。此外，与哮喘非恶化组相比，哮喘恶化组的 IHD 和 HF 的 HR 有所增加（调整后的 HR，1.29，95% CI = 1.24–1.34，IHD 和 aHR 1.68，95% CI = P < 0.001） 1.58–1.79，HF 时 P < 0.001）。然而，与对照组相比，哮喘患者中风的发生率降低（aHR = 0.96，95% CI = 0.93–0.99，P = 0.008）。患有哮喘的成年人更有可能患上心血管疾病。此外，严重的哮喘发作与心血管疾病发生率的增加显着相关。