北京大学护理学院
基本信息：
姓 名：卢言慧
毕业院校 ：首都医科大学
学 历：博士研究生
专 业：营养与食品卫生学博士；护理学博士后
所属教研室：内外科护理学教研室
职称/职务：研究员，硕/博士生导师，博士后合作导师
电 话：010-82805228
邮 箱：luyanhui@bjmu.edu.cn
科研项目：
2025-01至2028-12国家自然科学基金（面上项目）：肠道Akk菌源性维生素B12通过调控神经细胞重编程改善糖尿病认知障碍的作用及机制，主持，在研。
2021-01至2023-12国家自然科学基金（青年项目）：Akk菌通过调控NLRP3炎症小体改善2型糖尿病所致认知功能障碍的作用及其机制，主持，已结题。
2018-05至2021-01博士后课题基金一等资助：核糖糖基化对2型糖尿病患者认知功能的影响及机制研究，主持，已结题。
2019-01至2020.12北京市自然基金（青年项目）：肠道菌群代谢产物短链脂肪酸在2型糖尿病所致认知功能障碍中的作用及机制研究，主持，已结题。
2023-01至2023-12北京大学临床医学+X青年专项：肠道菌群代谢物乙酸通过泛素化-线粒体自噬途径调控NLRP3炎症小体改善糖尿病认知功能障碍机制研究，主持，已结题。
2024-01至2026-12国家自然科学基金（集成项目）：肠道菌群对代谢性疾病的调控作用与干预策略研究，骨干，在研。
2022-12至2027-12科技部“干细胞研究与器官修复”重点专项项目：母胎耐受机制及其在干细胞移植免疫耐受诱导中的应用，骨干，在研。
发表文章：
1.Chunyou Mao#*, Mengru Gao#, Shaokun Zang#, Yanqing Zhu#, Dandan Shen, Linan Chen, Liu Yang, Zhiwei Wang, Huibing Zhang, Weiwei Wang, Qingya Shen, Yanhui Lu*, Xin Ma*, Yan Zhang*. Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nature Communications. 2023 Nov 22;14(1):7620. (Q1, IF: 14.7)
2. Lin Wen, Yanhui Lu*, Xin Li, Yu An, Xiao Tan, Liangkai Chen*. Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis. Ageing Res Rev. 2025 Apr;106:102696. (Q1, IF=12.5)
3. Jie Zheng#, Yu An#, Yage Du, Ying Song, Qian Zhao, Yanhui Lu*. Effects of short-chain fatty acids on blood glucose and lipid levels in mouse models of diabetes mellitus: a systematic review and network meta-analysis. Pharmacological Research. 2024 Jan;199:107041. (Q1, IF: 9.1)
4. Tingjing Zhang#, Yu An#, Zhenfei Shen, Honghao Yang, Jinguo Jiang, Liangkai Chen, Yanhui Lu*, Yang Xia*. Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank. Alzheimer's research & therapy. 2024 May 11;16(1):106. (Q1, IF: 7.9)
5.Yanhui Lu, Hua Jiang, Huijing Zhang, Ruxue Li, Qi Zhang, Dan Luo, Xue Cai, Mingzi Li*. Serum oxidized low density lipoprotein serves as a mediator for the inverse relationship between serum D-ribose and cognitive performance in type 2 diabetic patients. Free Radical Biology and Medicine. 2021 Aug 1;171:91-98. (Q1, IF: 7.1)
6.Limin Cao#, Yu An#, Huiyuan Liu, Jinguo Jiang, Wenqi Liu, Yuhan Zhou, Mengyuan Shi, Wei Dai, Yanling Lv, Yuhong Zhao, Yanhui Lu*, Liangkai Chen*, Yang Xia*. Global epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis. BMC Medicine. 2024, 22:101. (Q1, IF: 7.0)
7.Tingjing Zhang#, Jiangen Song#, Zhenfei Shen, Kewan Yin, Feifei Yang, Honghao Yang, Zheng Ma, Liangkai Chen, Yanhui Lu*, Yang Xia*. Associations between different coffee types, neurodegenerative diseases, and related mortality: findings from a large prospective cohort study. The American journal of clinical nutrition. 2024 Aug 19:S0002-9165(24)00671-3. (Q1, IF: 6.5)
8. Xin Zhang#, Tianzhi Xie#, Shuang Zhou#, Yingxuan Yuan, Weixuan Chen, Jie Zheng, Xuebo Liu, Tian Yuan*, Yanhui Lu*, Zhigang Liu*. Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids. Food & Function. 2024 Feb 19;15(4):2249-2264. (Q1, IF: 5.1)
9. Zhaoming Cao, Yu An, Yanhui Lu*. Altered N6-methyladenosine modification patterns and transcript profiles contributes to cognitive dysfunction in high-fat induced diabetic mice. International Journal of Molecular Sciences. 2024 Feb 6;25(4):1990. (Q1, IF: 4.9)
10. Yu An#, Zhaoming Cao#, Yage Du, Guangyi Xu, Jingya Wang, Jie Zheng, Yanhui Lu*. Bidirectional two-sample, two-step mendelian randomisation study reveals mediating role for gut microbiota between vitamin B supplementation and Alzheimer’s disease. Nutrients. 2024 Nov 18;16(22):3929. (Q1, IF:4.8)
11.Ying Song#, Fangxiao Cheng#, Yage Du, Jie Zheng, Yu An, Yanhui Lu*. Higher adherence to the AMED, DASH, and CHFP dietary patterns is associated with better cognition among Chinese middle-aged and elderly adults. Nutrients. 2023 Sep 15(18), 3974. (Q1, IF: 4.8)
12. Yage Du#, Yu An#, Ying Song, Nan Li, Jie Zheng, Yanhui Lu*. Live and pasteurized Akkermansia muciniphila ameliorates diabetic cognitive impairment by modulating gut microbiota and metabolites in db/db mice. Experimental Neurology. 2024 May 21:114823. (Q1, IF:4.6)
13.Ying Song#, Yage Du#, Yu An, Jie Zheng, Yanhui Lu*. A systematic review and meta-analysis of cognitive and behavioral tests in rodents treated with different doses of D-ribose. Frontiers in Aging Neuroscience. 2022 Nov 9; 14:1036315. (Q2, IF: 4.1)
14.Yanhui Lu, Xinjun Jiang,Shuling Liu,Mingzi Li*. Changes in cerebrospinal fluid Tau and β-Amyloid levels in diabetic and prediabetic patients: a meta-analysis. Frontiers in Aging Neuroscience. 2018 Oct 11;10:271. (Q2, IF: 4.1)
15.Yage Du, Xiaoying Li, Yu An, Ying Song, Yanhui Lu*. Association of gut microbiota with sort-chain fatty acids and inflammatory cytokines in diabetic patients with cognitive impairment: A cross-sectional, non-controlled study. Frontiers in Nutrition. 2022 Jul 22; 9:930626. (Q2, IF: 4.0)
16. Yage Du, Liuqing Yang, Yu An, Ying Song, Yanhui Lu*. Health-related quality of life and associated factors in elderly individuals with dyslipidemia in rural Northern China. Quality of Life Research. 2023 Dec;32(12):3547-3555. (Q1, IF: 3.3)
17.Yanhui Lu, Yu An, Huanling Yu, Fengyuan Che, Xiaona Zhang, Hongguo Rong, Rong Xiao*. Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals. Metabolic Brain Disease. 2017 Aug;32(4):1089-1097. (Q2, IF: 3.2)
18.Yanhui Lu, Pengbo Xing, Xue Cai, Dan Luo, Ruxue Li, Cathy Lloyd, Norman Sartorius, Mingzi Li*. Prevalence and risk factors for diabetic peripheral neuropathy in type 2 diabetes in 14 countries: the INTERPRET-DD study. Frontiers in Public Health. 2020 Oct 20;8:534372. (Q2, IF: 3.0)
19.Zhaoming Cao*, Yage Du, Guangyi Xu, He Zhu, Yinchao Ma, Ziyuan Wang, Shaoying Wang, Yanhui Lu*. From diabetes to dementia: identifying key genes in the progression of cognitive impairment. Brain Sciences. 2024;14(10):1035. (Q3, IF:2.7)
20.Yanhui Lu, Yu An, Jin Guo, Xiaona Zhang, Hui Wang, Hongguo Rong, Rong Xiao1*. Dietary intake of nutrients and lifestyle affect the risk of mild cognitive impairment in the Chinese elderly population: a cross-sectional study. Frontiers in Behavioural Neuroscience. 2016 Nov 29;10:229. (Q2, IF: 2.6)
21. Yage Du#, Qi Zhang#, Xiaolan Zhang, Ying Song, Jie Zheng, Yu An*, Yanhui Lu*. Correlation between inflammatory biomarkers, cognitive function and glycemic and lipid profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Clinical Biochemistry. 2023 Nov; 121-122:110683. (Q2, IF: 2.5)
22. Yanhui Lu, Yu An, Chenyan Lv, Weiwei Ma, Yuandi Xi, Rong Xiao*. Dietary soybean isoflavones in Alzheimer’s disease prevention. Asia Pacific Journal of Clinical Nutrition. 2018;27(5):946-954. (Q4, IF: 1.3)
23.Jie Zheng#, Fangxiao Cheng#, Yage Du, Ying Song, Zhaoming Cao, Mingzi Li, Yanhui Lu*. Metabolic signatures and potential biomarkers in the progression of type 2 diabetes mellitus with cognitive impairment patients: A cross-sectional study. Interdisciplinary Nursing Research. 2023 February 2(1):p 19-26.
所获奖项：
2024年 北京市优秀农工党员
2019-09 北京大学军训嘉奖令
2018-12 北京大学护理学院青年教师比赛一等奖
社会兼职：
国家自然基金委项目评审专家
教育部学位论文评审专家
云南省科技战略(评审)专家
Nursing Communication杂志主编
中华行为医学与脑科学杂志编委
中华糖尿病杂志编委
《中国医药生物技术》杂志第三届编委会常务编委
中西医结合护理杂志(中英文)编委
北美华人营养学会会员
中国营养学会营养与免疫分会第一届委员会委员
中国营养学会特殊营养分会第五届委员会委员
中国健康管理协会护理分会第一届理事会常务理事
北京市护理学会护理管理专业委员会委员
北京大学护理学院学位评定分委员会委员
International Journal of Surgery审稿人
Obesity Reviews审稿人
Food&Function审稿人
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