黄璇

泰然健康网
2025-07-24 01:33

主要科研成果

先后主持国家级自然科学基金课题5项（完成3项），主持省自然科学基金项目等3项，授权国家发明专利3项。在国内外权威刊物发表学术论文二十余篇，其中第一作者或通讯作者12篇（中国科学院SCI期刊分区为一区SCI论文1篇，二区SCI论文4篇），累计论文引用次数超过600次。

1、主持科研课题

[1] 2022.1-2025.12：国家自然科学基金面上项目“TRIM65基因敲除促进肿瘤相关巨噬细胞M2型极化在肺癌中的作用及机制”（32170793），58万，主持

[2] 2023.1-2025.12：江西省自然科学基金杰出青年基金项目“E3泛素连接酶TRIM47促进肝细胞癌发生发展的机制研究”（20224ACB216013），20万，主持

[3] 2021.1-2023.12：江西省自然科学基金项目面上项目“靶向TRIM14的多肽药物在动脉粥样硬化中的作用及机制”（20212BAB206086），10万，主持

[4] 2020.1-2023.12：国家自然科学基金地区基金项目“TRIM65在急性肺损伤中的作用及其机制研究”（31960147），39万，主持

[5] 2017.1-2020.12：国家自然科学基金地区基金项目“TRIM14在非小细胞肺癌发生发展中的作用及机制”（81660390），38万，主持，已结题

[6] 2014.1-2016.12：国家自然科学基金青年基金项目“基于S期激酶相关蛋白2的抗肿瘤多肽药物筛选与应用”（81301964），23万，主持，已结题

2、发表代表性论文

[1] Lei Zhou, Qi Zhang, Qing Zhu, Yuan Zhan, Yong Li*, Xuan Huang*, Role and therapeutic targeting of glutamine metabolism in non-small cell lung cancer, Oncology Letters, 25:159, 2023.

[2] Yong Li, Qi Zhang, Na Li, Liting Ding, Jinping Yi, Yue Xiao, Shibiao Chen, Xuan Huang*, Ataxin-10 inhibits TNF-α-induced endothelial inflammation via suppressing interferon regulatory factor-1, Mediators of Inflammation, 2021: 7042148, 2021.

[3] Yingjie Huang, Yue Xiao, Xuekang Zhang*, Xuan Huang*, Yong Li*, The emerging roles of tripartite motif proteins (TRIMs) in acute lung injury, Journal of Immunology Research, 2021:1007126, 2021.

[4] Liting Ding#, Yang Fang#, Yong Li, Qinghua Hu, Meiling Ai, Keyu Deng, Xuan Huang*, Hongbo Xin*, AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis, Journal of Cellular and Molecular Medicine, 25(6): 3019-3030, 2021.

[5] Xuan Huang, Yong Li, Daping Fan, Hongbo Xin*, Mingui Fu*, TRIM14 promotes endothelial activation via activating NF-κB signaling pathway, Journal of Molecular Cell Biology,12(3): 176-189, 2020.

[6] Xuan Huang, Yong Li, Mingui Fu, Hongbo Xin*, Polarizing macrophages in vitro, Methods in Molecular Biology, 1784: 119-126, 2018.

[7] Yong Li#, Xuan Huang#, Shengping Huang#, Hui He, Tianhua Lei, Fatma Saaoud, Xiaoqiang Yu, Ari Melnick, Anil Kumar, Christopher J Papasian, Daping Fan, Mingui Fu*, Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury, Signal Transduction and Targeted Therapy, 2: e17066, 2017. (#Co-first authors)

[8] Xuan Huang, Mingjie Huang, Lingbao Kong, YongLi*, miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma, Cell Proliferation, 48: 593-599, 2015.

[9] Wei Wang#, Xuan Huang#, Hong-Bo Xin, Mingui Fu, Aimin Xue, Zhao-Hui Wu*, TRAF family member-associated NF-κB activator(TANK) inhibits genotoxic nuclear factor κB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase, Journal of Biological Chemistry, 290(21): 13372-13385, 2015.(#Co-first authors)

[10] Xuan Huang, Yong Li, Hui Fang, Congyi Zheng*, Establishment of persistent infection with foot-and-mouth disease virus in BHK-21 cells, Virology Journal, 8: 169, 2011.

[11] Xuan Huang, Yong Li, Congyi Zheng*, A novel single-cell quantitative real-time RT-PCR method for quantifying foot-and-mouth disease viral RNA, Journal of Virological Methods, 155(2): 150-156, 2009.