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酮体代谢与阿尔茨海默病

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2025-09-08 14:05

酮体代谢与阿尔茨海默病

作者单位:

西安交通大学,西安交通大学,西安交通大学

基金项目:

国家自然科学基金(31070740，31370844)，中央高校基本科研业务费专项资金(08143008，08143101)资助项目

Ketone Bodies Metabolism and Alzheimer′s Disease

Author:

SHI Le

Center of Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi′an Jiaotong University, Xi′an 710049, China
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LONG Jian-Gang

LIU Jian-Kang

Affiliation:

XI'AN JIAOTONG UNIVERSITY,XI'AN JIAOTONG UNIVERSITY,XI'AN JIAOTONG UNIVERSITY

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (31070740, 31370844), the Fundamental Research Funds for the Central Universities (08143008, 08143101)

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摘要:

阿尔茨海默病(Alzheimer's disease，AD)是老年痴呆症的一种主要类型，也是神经退行性疾病中发病率最高的一种疾病．随着我国老龄人口的持续上升，AD患者人数也呈增长趋势．研究表明，脑内葡萄糖代谢的降低远早于β淀粉样沉淀发生，而酮体是脑内替代葡萄糖的主要能量来源．因此，脑中能量代谢底物转换为酮体是AD早期代谢特征．目前，AD病理进程中酮体调控的机制还不清楚．深入了解AD发生、发展过程中酮体代谢的分子机制，对于寻找AD早期诊断标志物、探索AD的防治方法具有重要意义．本文就酮体代谢及其在AD中的研究进展进行综述．

Abstract:

Alzheimer's disease (AD) is the most common type of dementia, and has the highest incidence rate in neurodegenerative disorders. As the aged population robustly arises in China, the number of patients with AD is increasing accordingly. Studies show that decline in glucose metabolism occurs prior to amyloid deposits, and ketone bodies are the main alternative substrates for glucose in brain. Thus, the bioenergetic shift to ketone bodies is a characteristic of AD at early stage. At present, the mechanism of regulation of ketone bodies metabolism in AD pathogenesis is still unknown. In-depth understanding of ketone bodies metabolism involved in the occurrence and process of AD will lay a foundation in looking for new markers in early diagnosis and exploring prevention strategy of AD. Here we review AD-related ketone bodies metabolism and its research progress.

引用本文

时乐,龙建纲,刘健康.酮体代谢与阿尔茨海默病[J].生物化学与生物物理进展,2015,42(4):323-328

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