苏州医学院公共卫生学院
1. 近年发表的主要论文（*通讯作者）：
Publication list
ISI Researcher ID: http://www.researcherid.com/rid/K-8337-2016
Papers in ISI indexed journals
Year 2024
Qianlei Yang#; Ting Zhang#; Jian Liu#; Hui Lu; Chen Zhao; Chunchun Li; Koichi Kato; Dapeng Wang*; Yan An*. Sustained high expression of NRF2 inhibits cell apoptosis in arsenite-transformed human keratinocytes.Food and Chemical Toxicology.2024, 191:114875.
PMID: 39033872
DOI: 10.1016/j.fct.2024.114875
Yuanhui Zhu#; Qianlei Yang;#; Jie Gu; Zhicheng Chen; Nan Jing; Tingxu Jin; Jiayuan Lin; Xin Wang; Jingwen Hu; Guixiang Ji*; Yan An*. ‘Environmental standard limit concentration’ arsenic exposure is associated with anxiety, depression and autism-like changes in early-life stage zebrafish. Journal of Hazardous Material. 2024,469:133953.(Top Journal)
PMID: 38461670
DOI: 10.1016/j.jhazmat.2024.133953
Tingxu Jin#; Tongtong Huang#; Tianxue Zhang; Quan Li; Cheng Yan; Qian Wang; Xiufang Chen; Jing Zhou; Yitong Sun; Wenqing Bo; Ziqi Luo; Haodong Li; Yan An*. A Bayesian Benchmark Concentration Analysis for Urinary Fluoride and Intelligence in Adults in Guizhou, China. Science of The Total Environment. 2024：171326.(Top Journal)
PMID: 38460703
DOI: 10.1016/j.scitotenv.2024.171326
Year 2023
Qianlei Yang#; Yan Rui#; Jie Zhang#; Ting Zhang Aojun Ye; Xinghua Qiao; Koichi Kato;Chang Chen; Yan AN. Reductive Stress Induced by NRF2/G6PD through Glucose Metabolic Reprogramming Promotes to Malignant Transformation in Arsenite-Exposed Human Keratinocytes. Science of The Total Environment. 2023，896: 165207.(Top Journal)
PMID: 37391132
DOI: 10.1016/j.scitotenv.2023.165207
Rui Yan#; Jie Ding#；Xiaoyun Zhang; Tingxu Jin; Shudi Shi; Xirui Wang; Yu Zheng; Heran Li; Hengdong Zhang;
Yan AN. Lead acetate induces cartilage defects and bone loss in zebrafish embryos by disrupting the GH/IGF-1
axis.Ecotoxicology and Environmental Safety. 2023, 253:114666.(Top Journal)
PMID: 36812871
DOI: 10.1016/j.ecoenv.2023.114666
Before 2022
Qianlei Yang #; Rui Yan #; Yuemei Mo#; Haixuan Xia; Hanyi Deng; Xiaojuan Wang; Chunchun Li; Koichi Kato;
Hengdong Zhang; Tingxu Jing; Jie Zhang; Yan AN.The Potential Key Role of the NRF2/NQO1 Pathway in
the Health Effects of Arsenic Pollution on SCC. International Journal of Environmental Research and Public
Health. 2022, 19(13): 8118.
PMID: 35805773
DOI: 10.3390/ijerph19138118
Rui Yan#; Jie Ding#; Yuanjie Wei; Qianlei Yang; Xiaoyun Zhang; Hairu Huang; Zhuoyue Shi; Yue Feng; Heran Li;
Hengdong Zhang; Wenjun Ding; Yan AN. Melatonin prevents NaAsO2-induced developmental cardio-
toxicity in zebrafish through regulating oxidative stress and apoptosis. Antioxidants. 2022, 11(7): 1301.(Top Journal)
PMID: 35883792
DOI: 10.3390/antiox11071301
Jie Ding; Rui Yan; Luna Wang; Qianlei Yang; Xiaoyun Zhang; Nan Jing; Yuanjie Wei; Hengdong Zhang; Yan AN. Using Alizarin Red Staining to Detect Chemically Induced Bone Loss in Zebrafish Larvae. JoVE-Journal of Visualized Experiments.2021, 178: e63251.
PMID: 35037650
DOI: 10.3791/63251
Qi Kong#; Hanyi Deng#; Chunchun Li#; Xiaojuan Wang; Yasuyo Shimoda; Shasha Tao; Koichi Kato; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. Sustained expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells. Science of The Total Environment. 2021, 756: 143840. (Top Journal)
PMID: 33261869
DOI: 10.1016/j.scitotenv.2020.143840
Runa Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang; Yasuyo Shimoda; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety. 2020, 201: 110820. (Top Journal)
PMID: 32531574
DOI: 10.1016/j.ecoenv.2020.110820
Jiaoyuan Mao#; Qianlei Yang#; Makoto Miyazawa; Motofumi Miura; Luna Wanga; Haixuan Xiaa; Koichi Kato; Kenzo Yamanaka*; Yan AN*. Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics. Journal of Trace Elements in Medicine and Biology. 2020, 61: 126544.
PMID: 32416464
DOI: 10.1016/j.jtemb.2020.126544
Jing wu#; Yiping Ni#; Qianlei Yang#; Jiayuan Mao; Yasuyo Shimoda; Xuerui Zhu; Luna Wang; Haixuan Xia; Shasha Tao; Koichi Kato; Jie Zhang; Dapeng Wang*; Kenzo Yamanaka*; Yan AN*. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes. Science of The Total Environment. 2020, 734: 139425. (Top Journal)
PMID: 32450402
DOI: 10.1016/j.scitotenv.2020.139425
Jing Wu#, Jie Zhang#, Jihua Nie#, Junchao Duan, Yanfeng Shi, Lin Feng, Xiaozhe Yang, Yan AN*, Zhiwei Sun*. The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells. Toxicology Research. 2019, 8(5):731-740.
PMID: 31588350
DOI: 10.1039/c9tx00112c
Qianlei Yang#; Hanyi Deng#; Haixuan Xia#; Mengchuan Xu; Guotao Pan; Jiayuan Mao; Shasha Tao; Kenzo Yamanaka*; Yan AN*. High Nrf2 expression predicted poor prognosis in patients with lung cancer: A meta-analysis of cohort studies. Free Radical Research. 2019, 1-9.
PMID: 31298052
DOI:10.1080/10715762.2019.1642472
Qianlei Yang#; Zhen Zhu#; Luna Wang; Haixuan Xia; Xiaojuan Wang; Jing Wu; Koichi Kato; Heran Li; Jie Zhang*; Kenzo Yamanaka*; Yan AN*. The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. Environmental Toxicology and Pharmacology. 2019, 69:66-71.
PMID: 30959417
DOI:10.1016/j.etap.2019.04.001
Jing wu; Yiping Ni; Xiaojuan Wang; Qianlei Yang;Jiayuan Mao; Jian Tong; Jie Zhang*; Yan AN*. Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells. Journal of Toxicology and Environmental Health-part A.2019,82(18):990-996.
PMID: 31679505
DOI:10.1080/15287394.2019.1686108.
Jiting Liu; Li Zhang; Lixia Feng; Ming Xu; Yue Gao; Peng Zhou; Zhengmin Yu; Baoli Zhu; Yan AN*; Hengdong Zhang*. Association Between Single Nucleotide Polymorphism (rs4252424) in TRPV5 Calcium Channel Gene and Lead Poisoning in Chinese Workers. Molecular Genetics & Genomic Medicine. 2019; e562. https://doi. org/10.1002/mgg3.562 .
Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun,Wei Gong, Qiaoyun Zhang, Baoli Zhu, Yan An*. Association between Polymorphism of Exportin-5 andSusceptibility to Lead Poisoning in a Chinese Population. International Journal of Environmental Research and Public Health.2017, 14, 36.
DOI:10.3390/ijerph14010036
Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang;Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong; KenzoYamanaka; Jie Zhang*; Yan An*. Total Arsenic andSpeciation Analysis of Saliva and Urine Samples from Individuals Living inChronic Arsenicosis Area in China. EnvironmentalHealth and Preventive Medicine. 2017,22:45.
DOI:10.1186/s12199-017-0652-5
Xing Liu; Bin Sun;Xiaojuan Wang; Jihua Nie; Zhihai Chen; Yan AN*; Jian Tong*. Synergistic Effect of Radon and SodiumArsenite on DNA Damage in HBE Cells. EnvironmentalToxicology and Pharmacology. 2016,41: 127-131.
DOI:10.1016/j.etap.2015.11.013
Dapeng Wang; Yuan Ma; XuYang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; ChunchunLi; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan AN*. Hypermethylation of Keap1 Gene Inactivates Its Functionand Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced HumanKeratinocyte Transformation. Free RadicalBiology and Medicine. 2015, 89:209-219.(Top Journal)
DOI：10.1016/j.freeradbiomed.2015.07.153
Xu Yang, Dapeng Wang, Yuan Ma, Xiguo Xu, Yingying Zhao, Zhen Zhu, Xiaojuan Wang, Hanyi Deng, ChunchunLi, Fenfang Gao, Jian Tong, Kenzo Yamanaka, Yan AN*. Continuous Activation of Nrf2 and Its Target AntioxidantEnzymes Leads to Arsenite-Induced Malignant Transformation of Human BronchialEpithelial Cells. Toxicology and AppliedPharmacology. 2015, 289:231-239. (Top Journal)
DOI:10.1016/j.taap.2015.09.020
Huanyu Jin, Hua Yin,Yan AN*. The effect of gamma ray on thethermo-mechanical property of silk fibroin. ThermalScience. 2013, 17(5): 1521-1522.
DOI: 102298/TSCI1305521J
Yan AN*, Koichi Kato , Masayuki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka*. Specific induction of oxidative stress in terminal bronchiolar Clara cellsduring dimethylarsenic-induced lung tumor promoting process in mice. Cancer Letters.2005,230(1): 57-64.(Top Journal)
DOI:10.1016/j.canlet.2004.12.029
Yan AN*, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato,Masayuki Nakano, Shoji Okada, Kenzo Yamanaka*. Immunohistochemical analysis ofoxidative DNA damage in arsenic-related human skin samples fromarsenic-contaminated area of China. CancerLetters. 2004, 214(1): 11-18.(Top Journal)
DOI:10.1016/j.canlet.2004.04.005
2. 专利
发明专利
【1】Dimethylarsinous acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/088303】【US 20230314407 A1】
【2】Dimethylmonothioarsinic acid-induced Malignantly Transformed Cell Line of Human Keratinocytes and Use thereof. 【PCT/CN2021/077088】【US 2023-0159910 A1】
【3】一种线粒体自噬抑制剂在制备治疗砷至细胞恶性转化的疾病药物中的应用【ZL2022107802224】
【4】硫代二甲基胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021101095403】
【5】二甲基亚胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021103053231】
实用新型专利
【1】条带切割装置【ZL2018201134810】.
【2】一种用于涂覆蛋白条带的盒【ZL2018201299739】
【3】一种牙刷【ZL2018217130627】
【4】用于细胞培养的冻存盒【ZL2019210013294】
【5】转盘式试管架【ZL2019210004789】
【6】一种变容式洗碗机【ZL2019218943380】
【7】一种便于清洗的榨汁杯【ZL2019218945259】
【8】一种衣物脱水拧干装置【ZL2019218655379】
【9】一种化学药品辅助称量装置 【ZL202020770757X】
【10】一种密封性好的制胶装置 【ZL2020203907933】
【11】一种灭菌指示带切割器 【ZL2020206768928】
【12】夹闭式灭菌指示带切割器 【ZL2020206786485】
【13】一种易于批量清洗移液管的转换器【ZL2020208994247】
【14】一种简易小鼠粪尿分离及收集装置【ZL2020207334485】
【15】一种脚踩式酒精喷壶【ZL2020207715491】
【16】一种western blot抗体洗脱装置【ZL2021203206533】
【17】搅拌器【ZL2021205452710】
【18】一种溢流自清洁养殖缸【ZL2021207446343】
【19】一种便于使用的手指型指甲锉【ZL2021208273727】
【20】蛋白质提取冰盒【ZL2021213007220】
【21】一种斑马鱼胚胎和幼鱼的观察装置【ZL2021221124917】
【22】一种基于户外出行的晴雨伞背包【ZL2021222911483】
【23】一种细胞划痕实验装置【ZL202122516354X】
【24】一种斑马幼鱼心脏解剖用镊子刀【ZL202122454929X】
【25】可折叠干果处理装置）【2021226100726】
【26】一种微量离心管开盖器【ZL202220498263X】
【27】一种平板保护套【ZL2022207041411】
【28】一种基于冻存管的运输装置【ZL2022208332984】
【29】一种96孔板加样装置【ZL2022216802106】
【30】一种医用组织镊【ZL2022222346488】
【31】一种switch游戏机保护套【ZL2022224013361】
【32】一种新型核酸提取用过滤装置【ZL2022231335497】
【33】一种细胞培养用传代装置【ZL2023202030970】
【34】PVDF膜自定义尺寸裁剪装置【ZL2023202094703】
【35】一种细胞运输容器保护装置【ZL2023206320582】
【36】一种多功能细胞培养液存取装置【ZL2023202129933】
【37】一种可循环使用的光敏性离心管避光套【ZL2023207335316】
【38】一种离心后细胞重悬仪器【ZL2023203671572】
【39】一种用于Western blot实验的切膜装置【ZL2023205990750】
【40】一种细胞侵袭实验用Transwell小室【ZL2023203819724】
【41】一种斑马鱼卵的筛选装置【ZL2023211892350】
【42】一种用于细胞提取的细胞刷【ZL2023204281808】
【43】一种易于分离上清液的EP管【ZL2023205007849】
【44】一种免疫荧光实验用六孔板装置【ZL20232050079】
【45】一种细胞实验光照箱【ZL2023204094214】
【46】一种细胞实验用培养装置【ZL2024218878359】
3. 主（参）编著作
[1] 参编：《环境毒理学基础》，人民卫生出版社，2024年6月 第四版（ISBN 978-7-04-062198-3）.
[2] 参编：《环境毒理学基础》，人民卫生出版社，2018年11月 第三版（ISBN 978-7-04-050623-5）.
[3] 参编：《毒理学基础》，人民卫生出版社，2017年8月 第七版（ISBN 978-7-117-24633-0）.
[4] 参编：《现代环境毒理学》，中国环境出版社，2015年12月 第一版（ISBN 978-7-5111-2381-7 ）.
[5] 参编: 《毒理学试验方法与技术》，人民卫生出版社，2018年3月 第四版（ISBN 978-7-117-27879-9）
[6]主编：《国家污染物环境健康风险名录.生物分册》，中国环境出版社，2013年12月 第一次印刷（36万字， ISBN 978-7-5111-1678-9）.
相关知识
兰州大学公共卫生学院
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【顾雪平】苏州市康复医院
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公共健康学院开展2018年预防医学座谈会
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