首页 > 资讯 > 茶叶减肥降脂机制研究进展

茶叶减肥降脂机制研究进展

摘要: 肥胖是由于食欲调节和能量代谢功能长期紊乱引起的体内脂肪积累。肥胖与多种疾病密切相关,因此寻求高效、安全的减肥药物成为人们的共同愿望。茶叶因其良好的降脂减肥效果,日益引起国内外众多学者的关注。近年来,茶叶减肥机理成为研究的热点,并取得了显著成效。本文综述了最近几年对茶叶减肥作用的机理研究,即茶叶及其组分抑制营养吸收、改善脂质代谢、促进脂肪细胞凋亡和调节肥胖相关基因等方面的研究进展。 

关键词: 肥胖;  /  茶叶;  /  减肥机理;  

Abstract: Obesity may occur after long period of disoders in appetite and energy metabolism regulations.Obesity is strongly associated with many diseases.Therefore, searching for the high effective and safe anti-obesity medicine has become the common aspiration of people.Tea, with its putative function of anti-obesity, has attracted more and more attention all over the world.In recent years, tens of literatures were focused on the mechanism of the anti-obesity effects of tea.In this paper, recent progress on tea anti-obesity mechanism was reviewed, including inhibiting the absorption of nutritients, improving lipid metabolism, promoting lipoapoptosis, regulation of obesity-related genes, and a plausible pathway.

[1]

PARK K W, LEE J E, PARK K M.Diets containing Sophora japonica L.prevent weight gain in high-fat diet-induced obese mice[J].Nutr Res, 2009, 29 (11) :819-824.

[2]

GUO Y, WU G, SU X, et al.Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet[J].Nutr Res, 2009, 29 (9) :656-663.

[3]

EJAZ A, WU D, KWAN P, et al.Curcumin inhibits adipogenesis in3T3-L1adipocytes and angiogenesis and obesity in C57/BL mice[J].The Journal of nutrition, 2009, 139 (5) :919-925.

[4] 陆志强.减肥药的不良反应及正确使用[J].中国处方药, 2003, 9:88-91. [5]

HUANG H C, LIN J K.Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet[J].Food&function, 2012, 3 (2) :170-177.

[6]

CROZIER A, JAGANATH I B, CLIFFORD M N.Dietary phenolics:chemistry, bioavailability and effects on health[J].Natural Product Reports, 2009, 26 (8) :1001-1043.

[7]

ZHAO Y, CHEN P, LIN L, et al.Tentative identification, quantitation, and principal component analysis of green pu-erh, green, and white teas using UPLC/DAD/MS[J].Food Chemistry, 2011, 126 (3) :1269-1277.

[8]

LIN J K, LIN-SHIAU S Y.Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols[J].Molecular Nutrition&Food Research, 2006, 50 (2) :211-217.

[9]

OI Y, HOU I C, FUJITA H, et al.Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid[J].Phytotherapy research:PTR, 2012, 26 (4) :475-481.

[10]

UCHIYAMA S, TANIGUCHI Y, SAKA A, et al.Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo[J].Nutrition, 2011, 27 (3) :287-292.

[11]

GONDOIN A, GRUSSU D, STEWART D, et al.White and green tea polyphenols inhibit pancreatic lipase in vitro[J].Food Research International, 2010, 43 (5) :1537-1544.

[12]

SHISHIKURA Y, KHOKHAR S, MURRAY B S.Effects of tea polyphenols on emulsification of olive oil in a small intestine model system[J].Journal of Agricultural and Food Chemistry, 2006, 54 (5) :1906-1913.

[13]

IKEDA I, TSUDA K, SUZUKI Y, et al.Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats[J].The Journal of Nutrition, 2005, 135 (2) :155-159.

[14] 范志飞, 曾维才, 戴吉领, 等.表没食子儿茶素没食子酸酯与猪胰脂肪酶的相互作用[J].食品科学, 2012, 34 (7) :20-23. [15]

BOSE M, LAMBERT J D, JU J, et al.The major green tea polyphenol, (-) -epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice[J].The Journal of Nutrition, 2008, 138 (9) :1677-1683.

[16]

JOHNSTON K, SHARP P, CLIFFORD M, et al.Dietary polyphenols decrease glucose uptake by human intestinal Caco-2cells[J].FEBS Letters, 2005, 579 (7) :1653-1657.

[17]

ZHONG L, FURNE J K, LEVITT M D.An extract of black, green, and mulberry teas causes malabsorption of carbohydrate but not of triacylglycerol in healthy volunteers[J].The American Journal of Clinical Nutrition, 2006, 84 (3) :551-555.

[18]

VENABLES M C, HULSTON C J, COX H R, et al.Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans[J].The American Journal of Clinical Nutrition, 2008, 87 (3) :778-784.

[19]

PARK J H, JIN J Y, BAEK W K, et al.Ambivalent role of gallated catechins in glucose tolerance in humans:a novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption[J].Journal of Physiology and Pharmacology:an Official Journal of the Polish Physiological Society, 2009, 60 (4) :101-109.

[20]

BAHORUN T, LUXIMON-RAMMA A, NEERGHEEN-BHUJUN V S, et al.The effect of black tea on risk factors of cardiovascular disease in a normal population[J].Preventive Medicine, 2012, 54:98-102.

[21]

HOU Y, SHAO W, XIAO R, et al.Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model[J].Experimental Gerontology, 2009, 44 (6-7) :434-439.

[22]

GOTO T, SAITO Y, MORIKAWA K, et al.Epigallocatechin gallate changes mRNA expression level of genes involved in cholesterol metabolism in hepatocytes[J].The British Journal of Nutrition, 2012, 107 (6) :769-773.

[23]

PEREZ-JIMENEZ A, PERES H, RUBIO V C, et al.Effects of diet supplementation with white tea and methionine on lipid metabolism of gilthead sea bream juveniles (Sparus aurata) [J].Fish Physiology and Biochemistry, 2012, 39 (3) :661-670.

[24]

IKEDA I, HAMAMOTO R, UZU K, et al.Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats[J].Bioscience, Biotechnology, and Biochemistry, 2005, 69 (5) :1049-1053.

[25] 袁华兵, 钟婕, 易娟, 等.普洱茶提取物对饮食诱导肥胖大鼠脂质合成相关基因表达的影响[J].营养学报, 2009, 31 (2) :167-171. [26]

CHIANG C T, WENG M S, LIN-SHIAU S Y, et al.Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2cells[J].Oncology Research, 2005, 16 (3) :119-128.

[27]

WAY T D, LIN H Y, KUO D H, et al.Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2cells[J].Journal of Agricultural and Food Chemistry, 2009, 57 (12) :5257-5264.

[28]

KAO C C, WU B T, TSUEI Y W, et al.Green tea catechins:inhibitors of glycerol-3-phosphate dehydrogenase[J].Planta Medica, 2010, 76 (7) :694-696.

[29]

LEE M S, KIM C T, KIM I H, et al.Inhibitory effects of green tea catechin on the lipid accumulation in3T3-L1adipocytes[J].Phytotherapy Research:PTR, 2009, 23 (8) :1088-1091.

[30]

LEE M S, KIM C T, KIM Y.Green tea (-) -epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice[J].Annals of Nutrition&Metabolism, 2009, 54 (2) :151-157.

[31]

GONG J, PENG C, CHEN T, et al.Effects of theabrownin from pu-erh tea on the metabolism of serum lipids in rats:mechanism of action[J].Journal of Food Science, 2010, 75 (6) :H182-189.

[32]

NOMURA S, ICHINOSE T, JINDE M, et al.Tea catechins enhance the mRNA expression of uncoupling protein1in rat brown adipose tissue[J].The Journal of Nutritional Biochemistry, 2008, 19 (12) :840-847.

[33]

TOKIMITSU I.Effects of tea catechins on lipid metabolism and body fat accumulation[J].Biofactors, 2004, 22 (1-4) :141-143.

[34]

MURASE T, NAGASAWA A, SUZUKI J, et al.Beneficial effects of tea catechins on diet-induced obesity:stimulation of lipid catabolism in the liver[J].International Journal of Obesity and Related Metabolic Disorders:Journal of the International Association for the Study of Obesity, 2002, 26 (11) :1459-1464.

[35]

PARK H J, DINATALE D A, CHUNG M Y, et al.Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice[J].The Journal of Nutritional Biochemistry, 2011, 22 (4) :393-400.

[36]

CAO Z H, YANG H, HE Z L, et al.Effects of Aqueous Extracts of Raw Pu-erh Tea and Ripened Pu-Erh Tea on Proliferation and Differentiation of3T3-L1Preadipocytes[J].Phytotherapy Research:PTR, 2012, Online First.

[37]

KU H-C, LIU H-S, HUNG P-F, et al.Green tea (-) -epigallocatechin gallate inhibits IGF-I and IGF-IIstimulation of3T3-L1preadipocyte mitogenesis via the67-kDa lamininreceptor, but not AMP-activated protein kinase pathway[J].Molecular Nutrition&Food Research, 2012, 56 (4) :580-592.

[38]

CHAN C Y, WEI L, CASTRO-MU OZLEDO F, et al. (-) -Epigallocatechin-3-gallate blocks3T3-L1adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression[J].Life Sciences, 2011, 89 (21-22) :779-785.

[39]

LIN J, DELLA-FERA M A, BAILE C A.Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in3T3-L1adipocytes[J].Obesity Research, 2005, 13 (6) :982-990.

[40] 孙世利, 凌彩金, 刘军, 等.茶多酚与茶黄素对前脂肪细胞3T3-L1增殖与分化的影响[J].广东农业科学, 2011, 38 (12) :137-139. [41]

WU B T, HUNG P F, CHEN H C, et al.The apoptotic effect of green tea (-) -epigallocatechin gallate on3T3-L1preadipocytes depends on the Cdk2pathway[J].Journal of Agricultural and Food Chemistry, 2005, 53 (14) :5695-5701.

[42]

LU C, ZHU W, SHEN C L, et al.Green tea polyphenols reduce body weight in rats by modulating obesity-related genes[J].PloS One, 2012, 7 (6) :e38332.

[43]

YANG D J, HWANG L S.Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea[J].Journal of Chromatography A, 2006, 1119 (1-2) :277-284.

相关知识

普洱茶减肥降脂机制明确
茶叶健康与茶制品产业创新发展大会成功举办
减肥降脂喝什么茶比较好?推荐几种有效的茶叶,有助于减肥和降低血脂。
普洱茶有助降脂减肥
怎样喝荷叶茶减肥 4款自制荷叶茶让你快速消脂
喝茶叶能减肥吗
研究进展
肥宅福音!绿茶+柑橘多酚=减肥降脂新搭档!
微塑料的人体富集及毒性机制研究进展
减肥茶=茶叶+泻药?!

网址: 茶叶减肥降脂机制研究进展 https://m.trfsz.com/newsview308675.html