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左旋肉碱改善代谢综合征的作用及机制研究进展

泰然健康网
2024-12-06 21:32

摘要: 代谢综合征是一组以肥胖、血脂异常、高血压、高尿酸血症、高血糖以及胰岛素抵抗等为主要特征的临床综合征，是心血管疾病和糖尿病的重要危险因素。研究表明，左旋肉碱，即L-肉碱，对代谢综合征具有潜在改善作用。本文对人体L-肉碱的来源及L-肉碱改善代谢综合征主要组分，如肥胖、血脂异常等的作用及机制进行综述，并讨论了L-肉碱作为氧化三甲胺前体物质的潜在健康风险问题，为代谢综合征的防治及L-肉碱的合理摄食补充及应用提供理论依据及参考。

Abstract: Metabolic syndrome is a group of clinical syndromes, including obesity, dyslipidemia, hypertension, hyperuricemia, hyperglycemia and insulin resistance. These syndromes are critical risk factors for cardiovascular disease and diabetes. Recent studies indicate that L-carnitine exhibits potential improvement effects on metabolic syndrome. In the current study, the sources of L-carnitine for human and the effects and mechanisms of L-carnitine on the major components of metabolic syndrome, such as obesity and dyslipidemia, etc were summarized. The potential health risk of L-carnitine by serving as a dietary precursor for trimethylamine N-oxide was also discussed. This study provides theoretical basis and references for the treatment of metabolic syndrome and the rational dietary supplement and utilization of L-carnitine.

图 1 L-肉碱化学结构图

Figure 1. Chemical structure of L-carnitine

图 2 内源性L-肉碱合成途径

Figure 2. Endogenous L-carnitine synthesis pathway

图 3 L-肉碱改善肥胖的潜在机制

Figure 3. Potential mechanisms of L-carnitine on improving obesity

图 4 L-肉碱肠道代谢途径

Figure 4. Intestinal metabolic pathway of L-carnitine

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