生命早期环境内分泌干扰物暴露与儿童过敏性疾病关系的研究进展
摘要： 环境内分泌干扰物（ endocrine disruptor chemicals，EDCs）在结构上与类固醇激素相似，具有拟类固醇激素的免疫调节功能，可能影响免疫系统及过敏反应。双酚 A（bisphenol A，BPA）及三氯生（triclosan，TCS）是广泛添加于生活日用品及餐饮用品的 2种常见酚类 EDCs。动物实验发现，生命早期（包括胚胎和婴幼儿时期） BPA暴露可能与幼年期呼吸道过敏性疾病的发生有关。同时流行病学证据也显示， TCS可能与儿童湿疹性皮炎及呼吸道、消化道过敏性疾病有关。过敏性疾病是影响儿童健康的常见疾病，它是致敏原作用于机体引起的免疫反应异常及变应性炎症反应所致的一种疾病。 EDCs可通过影响辅助 T细胞（ Th1 /Th2）的功能，增加细胞因子及免疫球蛋白水平，影响免疫系统，可能与过敏反应有关。该文主要综述 BPA和 TCS与儿童过敏性疾病的关系及相关发病机制。
关键词: 环境内分泌干扰物, 双酚 A, 三氯生, 儿童过敏性疾病
Abstract:
Endocrine disruptor chemicals (EDCs) are similar to steroid hormones in molecular structure, and may have steroid-like disrupting effects on the immune system and influence the risk of allergic diseases. For example, bisphenol A (BPA) and triclosan (TCS) are commonly EDCs existing in the environment, and both BPA and TCS are widely added to daily necessities and catering products. Animal experiments found that prenatal BPA exposure may be associated with higher risk of respiratory allergic diseases in offspring. It was also founda few epidemiological studies that TCS exposure was associated with higher risks of eczema, and allergic disorders in respiratory system and digestive tracts in children. EDCs may increase cytokines and immunoglobulins levelsinterrupting the function of helper T cells (Th1/Th2) so as to affect the immune system, which might be associated with allergic reactions. This review mainly focused on the correlation between EDCs (BPA and TCS) and childhood allergic diseases and the underlying mechanisms.Key words: endocrine disruptor chemicals, bisphenol A, triclosan, children′s allergic disease
中图分类号:
R12
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