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刘志刚

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2024-12-21 13:59

2020年1月－至今，西北农林科技大学食品科学与工程学院，教授；

2020年8月－至今，德国人类营养研究所，访问研究员/洪堡学者；

2020年7月－至今，美国Cornell University，Department of Food Science，客座教授；

2019年7月－至今，美国康奈尔大学农业与生命科学学院食品科学系，客座副教授；

2015年9月－2017年1月，西北农林科技大学食品科学与工程学院，讲师；

2013年8月－2015年8月，美国南加州大学药学院，联合培养博士；

2010年9月－2015年6月，西北农林科技大学食品科学与工程学院，食品科学，博士；

2006年9月－2010年6月，西北农林科技大学食品科学与工程学院，食品质量与安全，工学学士。 [1]

本科课程：《食品营养学》、《食品化学安全性分析与控制教学实习》、《食品学科前沿讨论课》

研究生课程：《高级食品化学》、《食品科学Seminar》 [1]

主要从事食品营养与人类健康研究方向，包括：

1. 食品营养功能组分发掘与功效评价：结合我国特色食材资源和全民营养健康现状，发掘果蔬、粮油等传统食品原料中具有调节代谢、改善脑健康问题（情绪、社交、认知功能障碍等）等生理功能的可溶性膳食纤维、多酚和类胡萝卜素类功能成分；

2. 新型膳食模式对代谢综合征及神经退行性疾病的干预作用机制：利用多组学系统生物学研究方法探究限制性饮食模式对肥胖、糖尿病等代谢性疾病，以及衰老相关的阿尔兹海默症、帕金森症等神经退行性疾病的改善作用，揭示间歇性禁食、植物蛋白饮食、特殊氨基酸限制饮食通过调节“肠-肝-脑”轴调节机体微生态免疫平衡、干预系统性胰岛素抵抗、改善与衰老相关的中枢神经系统功能紊乱的分子机制。 [1]

研究发现了高脂高果糖等不合理膳食模式会诱导脑部胰岛素抵抗及认知功能障碍，并尝试探索了通过改变膳食结构和营养组分，干预由于遗传、衰老、不合理饮食、社会压力等因素引起的认知记忆功能紊乱及情绪变化。近年来在食品营养及生物化学领域共发表论文五十余篇，主要成果发表在食品营养与生物化学领域等具有国际影响力的期刊上，论文总引次数超过800余次，H-index 17，i10index 25。其中ESI前1%高被引论文3篇，封面文章1篇，参编英文专著1部。

近5年来主持包括国家自然科学基金面上项目、青年项目、陕西省重点研发计划、中国博士后特别资助、企业横向课题等科研项目10余项，荣获2018年陕西省科学技术进步奖二等奖（排名第二）及陕西省高等学校科学技术一等奖（排名第二）。目前任Frontiers in Aging Neuroscience审稿编辑，Free radical biology & medicine, Journal of Agricultural and Food Chemistry, Journal of Nutrition, Journal of Functional Foods等食品营养学杂志审稿人。美国营养学会、欧洲自由基研究学会会员。多次受邀参与多个国际重要学术会议，包括美国营养学会（American Societyof Nutrition）、美国加州自由基协会（Oxygen California Club）以及戈登会议（Gordon Research Seminar & Gordon Research Conference）、国际脂质科学与健康研讨会等国际会议并做学术报告。 [1]

1. 国家自然科学面上项目，No. 81871118，主持；

2. 国家自然科学基金青年项目，No. 81803231，主持；

3. 陕西省重点研发计划，No. 2018NY-100，2018-2020，主持；

4. 中国博士后科学基金委特别资助，No. 2018T1104，2018-2020，主持；

5. 陕西省高校科协青年人才托举计划，No. 201770201，2017-2019，主持；

6. 国家“十三五”重点研发计划，现代食品加工及粮食收储运技术与装备专项，项目子课题，No. 2017YFD0400200，2017-2021，子课题研究骨干；

7. 中国博士后科学基金面上资助，No. 2016M602867，2016/01- 2018/12，主持；

8. 西北农林科技大学博士科研启动基金，No. 2452015305，2015/9- 2018/9，主持。 [1]

1. William Shang（向玉龙）, 刘志刚《糖尿病自救攻略》Amazon KDP, 2020.（共同主编）

2. Zhigang Liu*, Harsh Sancheti, Enrique Cadenas*, and Fei Yin* (2015) Chapter 2: Energy-redox axis in mitochondria. Mitochondria in Liver Disease (Han, D. and Kaplowitz, N., Eds), pp. 29-43. CRC Press, Boca Raton. [1]

1. Zhigang Liu*#; Xiaoshuang Dai#; Hongbo Zhang; Renjie Shi; Yan Hui; Xin Jin; Wentong Zhang;Luanfeng Wang;Qianxu Wang; Danna Wang; Jia Wang; Xintong Tan; Bo Ren; Xiaoning Liu; Tong Zhao; Jiamin Wang; Junru Pan; Tian Yuan; Chuanqi Chu; Lei Lan; Fei Yin; Enrique Cadenas; Lin Shi*; Shancen Zhao*; Xuebo Liu*. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.Nature Communications 2020;11(1):855.

2. Xin Zhang; Qianhui Zou; Beita Zhao; Jingwen Zhang; Weiyang Zhao; Yitong Li; Ruihai Liu; Xuebo Liu;Zhigang Liu*. Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.Redox Biology 2020;32:101535.

3. Zhigang Liu#; Ling Li#; Shaobo Ma; Jin Ye; Hongbo Zhang; Yitong Li; Ali Tahir Sair; Junru Pan; Xiaoning Liu; Xiang Li; Shikai Yan; Xuebo Liu*. High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved. Journal of Agricultural and Food Chemistry2020;68(47):13697-13710.

4. Hongbo Zhang; Wentong Zhang; Duo Yun; Ling Li; Weiyang Zhao; Yitong Li; Xuebo Liu*;Zhigang Liu*. Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: Roles of FGF21 and bile acids. Journal of Nutritional Biochemistry 2020;83:108403.

5. Qianhui Zou; Xin Zhang; Xiaoshuang Liu; Yitong Li; Qiaoli Tan; Qin Dan;Tian Yuan; Xuebo Liu; Ruihai Liu; Zhigang Liu*. Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice. Food & Function 2020;11(7):6666-6679.

6. Luanfeng Wang; Bo Ren; Qian Zhang; Chuanqi Chu; Zhenting Zhao; Jianbin Wu; Weiyang Zhao; Zhigang Liu*, Xuebo Liu*. Methionine Restriction Alleviates High-Fat Diet-induced Obesity: Involvement of Diurnal Metabolism of Lipids and Bile Acids.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease2020;1866(11):165908.

7. Luanfeng Wang; Bo Ren; Yan Hui; Chuanqi Chu; Zhenting Zhao; Yuyu Zhang; Beita Zhao; Renjie Shi; Junli Ren; Xiaoshuang Dai; Zhigang Liu*; Xuebo Liu*. Methionine Restriction Regulates Cognitive Function in High-Fat Diet-Fed Mice: Roles of Diurnal Rhythms of SCFAs Producing-and Inflammation-related Microbes.Molecular Nutrition & Food Research 2020;64(17):2000190.

8. Jia Wang; TonghuiGeng; Qianhui Zou; Ningru Yang; Weiyang Zhao; Yitong Li; Xintong Tan; Tian Yuan; Xuebo Liu, and Zhigang Liu*. Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function. Journal of Functional Foods 2020;67:103857.

9. Bo Ren; Tian Yuan; Xinglin Zhang; Luanfeng Wang; Junru Pan; Yan Liu; Beita Zhao; Weiyang Zhao; Zhigang Liu*; Xuebo Liu*. Protective Effects of Sesamol on Systemic Inflammation and Cognitive Impairment in Aging Mice. Journal of Agricultural and Food Chemistry 2020;68(10):3099-3111.

10. AiziguliMulati; Shaobo Ma; Hongbo Zhang; Bo Ren; Beita Zhao; Luanfeng Wang; Xiaoning Liu; Tong Zhao; Svetlana Kamanova; Ali Tahir Sair; Zhigang Liu*; Xuebo Liu*. Sea-Buckthorn Flavonoids Alleviate High-Fat and High-Fructose Diet-Induced Cognitive Impairment by Inhibiting Insulin Resistance and Neuroinflammation. Journal of Agricultural and Food Chemistry 2020;68(21):5835-5846.

11. Shikai Yan; Renjie Shi; Ling Li; Shaobo Ma; Hongbo Zhang; Jin Ye; Jiamin Wang; Junru Pan; Qianxu Wang; Xiang Jin; Xuebo Liu; Zhigang Liu*. Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western-Diet-Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short-Chain Fatty Acids Production. Molecular Nutrition & Food Research 2019;63(23):e1900521.

12. Xintong Tan; Ling Li; Jia Wang; Beita Zhao; Junru Pan; Leran Wang; Xiao Liu; Xuebo Liu; Zhigang Liu*. Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes. Journal of Agricultural and Food Chemistry 2019;67(31):8510-8519.

13. Cover Article: Qianxu Wang; Mengzhen Jia; Yihang Zhao; Yan Hui; Junru Pan; Hongfei Yu; Shikai Yan; Xiaoshuang Dai; Xuebo Liu; Zhigang Liu*. Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure. Journal of Agricultural and Food Chemistry 2019;67(45):12441-12451.

14. Yihang Zhao; Qianxu Wang; Mengzhen Jia; Shangchen Fu; Junru Pan; Chuanqi Chu; Xiaoning Liu; Xuebo Liu; Zhigang Liu*. (+)-Sesamin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Memory Deficits via Suppression of Neuroinflammation. Journal of Nutritional Biochemistry 2019;64:61-71.

15. Tian Yuan; Chuanqi Chu; Rubing Shi; Tianlin Cui; Xinglin Zhang; Yihang Zhao; Xu Shi; Yan Hui; Junru Pan; Rui Qian; Xiaoshuang Dai; Zhigang Liu*; XueboLiu*. ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut-Brain Axis. Journal of Agricultural and Food Chemistry 2019;67(22):6190-6201.

16. Guoyuan Qi; Yashi Mi; Rong Fan; Zhigang Liu*; Xuebo Liu*. Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways. Journal of Agricultural and Food Chemistry 2019;67(18):5122-5134.

17. Zhigang Liu#; Xiaoning Liu#; Shunyi Luo; Chuanqi Chu; Dandan Wu; Runhua Liu; Lei Wang; Jiamin Wang; Xuebo Liu*. Extract of Sesame Cake and Sesamol Alleviate Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Memory Deficits. Journal of Functional Foods 2018;42:237-247.

18. Beita Zhao; Hua Liu; Jiamin Wang; Pujie Liu; Xintong Tan; Bo Ren; Zhigang Liu*; Xuebo Liu*. Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice. Journal of Agricultural and Food Chemistry 2018;66(12):3127-3136.

19. Rui Guo; Beita Zhao; Yijie Wang; Dandan Wu; Yutang Wang; Yafan Yu; Yuchen Yan; Wentong Zhang; Zhigang Liu*; Xuebo Liu*. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. Journal of Agricultural and Food Chemistry 2018;66(37):9667-9678.

20. Jia Wang; Zhuo Wang; Bing Li; Yu Qiang; Tian Yuan; Xintong Tan; Zihan Wang; Zhigang Liu*; Xuebo Liu*. Lycopene Attenuates Western-Diet Induced Cognitive Deficits via Improving Glycolipid Metabolism Dysfunction and Inflammatory Responses in Gut-Liver-Brain Axis. International Journal of Obesity 2018;43(9):1735-1746.

21. Jia Wang; Lixia Li; Zhuo Wang; Yifan Cui; Xintong Tan; Tian Yuan; Qian Liu; Zhigang Liu*; Xuebo Liu*.Supplementation of Lycopene Attenuates Lipopolysaccharide-Induced Amyloidogenesis and Cognitive Impairments via Mediating Neuroinflammation and Oxidative Stress. Journal of Nutritional Biochemistry 2018;56:16-25.

22. Front Cover Article: Zhigang Liu#; Yuwei Chen#; QinglianQiao; Yali Sun; Qian Liu; Bo Ren; Xuebo Liu*. Sesamol Supplementation Prevents Systemic Inflammation-Induced Memory Impairment and Amyloidogenesis via Inhibition of Nuclear Factor KappaB. Molecular Nutrition & Food Research 2017;61(5):10.

23. 刘学波; 刘小宁; 原田; 刘志刚* 芝麻酚的神经保护作用及分子机制《中国食品学报》2017;17(10):1-7.

24. Zhigang Liu#; Yali Sun#; QinglianQiao; Tong Zhao; Wentong Zhang; Bo Ren; Qian Liu; Xuebo Liu*. Sesamol Ameliorates High-Fat and High-Fructose Induced Cognitive Defects via Improving Insulin Signaling Disruption in the Central Nervous System. Food & Function 2017;8(2):710-719.

25. Zhigang Liu; Patil Ishan; Sancheti Harsh; Yin Fei; Cadenas Enrique*. Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and13C-NMR Study. Scientific Reports 2017;7(1):5391.

26. Qian Liu; Yaya Hu; Youfang Cao; Ge Song; Zhigang Liu*; Xuebo Liu*. Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain. Journal of Agricultural and Food Chemistry 2017;65(2):338-347.

27. Zhigang Liu; Bo Ren; Yihui Wang; Chen Zou; QinglianQiao; Zhijun Diao; Yashi Mi; Di Zhu; Xuebo Liu*. Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy. Scientific Reports 2017;7:45728.

28. Ge Song#; Zhigang Liu#; Luanfeng Wang; Renjie Shi; Chuanqi Chu; Man Xiang; Qi Tian; Xuebo Liu*. Protective Effects of Lipoic Acid Against Acrylamide-Induced Neurotoxicity: Involvement of Mitochondrial Energy Metabolism and Autophagy. Food &Function2017;8:4657-4667.

29. Guoyuan Qi#; Zhigang Liu#; Rong Fan; Ziru Yin; Yashi Mi; Bo Ren; Xuebo Liu*. Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells. Scientific Reports 2017;7(1):2275.

30. Qian Liu; Yuwei Chen; Chun Shen; Yating Xiao; Yutang Wang; Zhigang Liu*; Xuebo Liu*. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB Journal 2017;31(4):1494-1507.

31. Zhigang Liu; Qinglian Qiao; Yali Sun; Yuwei Chen; Bo Ren; Xuebo Liu*. Sesamol Ameliorates Diet-Induced Obesity in C57BL/6J Mice and Suppresses Adipogenesis in 3T3-L1 Cells via Regulating Mitochondria-Lipid Metabolism. Molecular Nutrition & Food Research 2017; 63(8):e1600717

32. 刘学波，张文彤，郭瑞，刘志刚高脂高果糖膳食影响脑认知功能的分子机制与研究进展《中国食品学报》 2016;16(10):1-9. EI

33. Zhigang Liu; Ge Song; Chen Zou; Gongguan Liu; Wanqiang Wu; Tian Yuan; Xuebo Liu. Acrylamide Induces Mitochondrial Dysfunction and Apoptosis in BV-2 Microglial Cells. Free Radical Biology & Medicine 2015;84:42-53.

34. Zhigang Liu; Ishan Y Patil; Tianyi Jiang; Harsh Sancheti; John P Walsh; Bangyan L Stiles; Fei Yin; Enrique Cadenas. High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity. PLoS One 2015;10(5):e0128274.

35. 刘学波，刘志刚线粒体介导食品功能因子活性与食品危害物毒性的分子机制《中国食品学报》2015;15(10):1-8. EI

36. Zhigang Liu; Qisen Xiang; Lihui Du; Ge Song; Yutang Wang; Xuebo Liu*. The Interaction of Sesamol with DNA and Cytotoxicity, Apoptosis, and Localization in HepG2 Cells. Food Chemistry 2013;141(1):289-296.

1. 一种具有改善和缓解压力作用的芝麻木酚素咀嚼片；已授权；专利授权国：中国；专利号：2017102429392；

2. 一种抗疲劳的苣荬菜运动饮料；已授权；专利授权国：中国；专利号：201710219898.5。 [1]

1. Intermittent Fasting Alleviates Diabetes-induced Cognitive Decline via Gut Microbiota-metabolites-brain Axis, American Society of Nutrition; Baltimore, Maryland, United States,2019 (Selected Oral Presentation).

2. The neuroprotective effects of sesamol and underlying molecular mechanisms. 3rdInternational Symposium of Food Science and Human Wellness; Changchun, Jilin, China, 2017 (Selected Oral Presentation).

3.芝麻酚改善认知记忆损伤的功能与分子机制探索，第三届中国食品科学青年论坛，中国·上海 (Speaker).

4.Liu, Z., Liu, X.*The neuroprotective effects of sesamol. 3rdChinese Institute of Food Science Youth Forum; Shanghai, China, 2017 (Selected Oral Presentation).

5.Liu, Z., Liu, X.*The Glorious history of sesame food，2017 Industry Conference of White Sesame in Pingyu Country; Pingyu, Henan, China, 2017 (Invited Speaker).

6.Liu, Z., Chen, Y., and Liu, X.*Sesamol supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB. International Conference on Aging Research; Hangzhou, Zhejiang, China, 2016 (Poster).

7.Liu, Z., Cadenas, E.*, Effect of lipoic acid on high-fat diet-induced alteration of synaptic plasticity and brain glucose metabolism. Gordon Research Conference: Oxidative Stress & Disease; Ventura, California, United States. 2015.3 (Selected Oral Presentation).

8.Liu, Z., Cadenas, E.*,High-fat diet induces a systemic insulin resistance that impairs synaptic Plasticity. Oxygen Club of California (OCC) World Congress; UC Davis, Davis, California, United States. 2014.5 (Poster). [1]