首页 > 资讯 > 补充左旋肉碱对血液透析成年患者血脂谱的影响：随机对照试验的系统评价和荟萃分析

补充左旋肉碱对血液透析成年患者血脂谱的影响：随机对照试验的系统评价和荟萃分析

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2024-12-28 13:07

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register hereBackground: Chronic kidney disease (CKD) affects 10% of the global population and leads to end-stage renal disease (ESRD). Hemodialysis is a common treatment for ESRD, but patients often have low carnitine levels, leading to dyslipidemia, a risk factor for cardiovascular disease and the leading cause of mortality.

背景：慢性肾病（CKD）影响全球人口的10%，并导致终末期肾病（ESRD）。血液透析是ESRD的常见治疗方法，但患者的肉碱水平通常较低，导致血脂异常，这是心血管疾病的危险因素，也是导致死亡的主要原因。

This study aimed to assess the effects of L-carnitine on lipid profiles in adult hemodialysis patients. .

本研究旨在评估左旋肉碱对成人血液透析患者血脂的影响。

Methods: A comprehensive search was conducted across the online databases from inception to June 2024 to identify randomized clinical trials (RCTs) evaluating the effects of L-carnitine on lipid profiles in hemodialysis patients. Data extraction and quality assessment were performed, focusing on primary outcomes, including changes in triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), and secondary outcomes including blood pressure (BP) and body mass index (BMI).

方法：从开始到2024年6月，对在线数据库进行了全面搜索，以确定评估左旋肉碱对血液透析患者血脂谱影响的随机临床试验（RCT）。进行数据提取和质量评估，重点是主要结果，包括甘油三酯（TG），总胆固醇（TC），高密度脂蛋白（HDL），低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）的变化，以及次要结果，包括血压（BP）和体重指数（BMI）。

Results: A total of 28 RCTs were eligible for the current systematic review, including 1340 hemodialysis patients (671 intervention, 669 control). There were no significant differences in the mean change of TG (SMD: -0.006; 95% CI, -0.272 to 0.259; P = 0.95), TC (SMD: -0.086; 95% CI, -0.253 to -0.079; P = 0.29), HDL (SMD: 0.060; 95% CI, -0.057 to 0.177; P = 0.29), LDL (SMD: -0.075; 95% CI, -0.274 to 0.123; P = 0.43), VLDL (SMD: -0.064; 95% CI, -0.272 to 0.142; P = 0.51), BMI (SMD: -0.025; 95% CI, -0.139 to 0.088; P = 0.56), systolic BP (SMD: 0.055; 95% CI, -0.110 to 0.220; P = 0.43), and diastolic BP (SMD: -0.028; 95% CI, 0.156 to 0.099; P = 0.56).

结果：共有28项随机对照试验符合当前系统评价的条件，包括1340名血液透析患者（671名干预，669名对照）。。

The same insignificant findings were observed after conducting a subgroup analysis based on the route of administration (intravenous vs. Oral). .

在根据给药途径（静脉注射与口服）进行亚组分析后，观察到相同的微不足道的发现。

Conclusion: L-carnitine supplementation does not significantly change and improve the serum lipid profile, including TG, TC, HDL, LDL, and VLDL levels. Additionally, it has no notable effects on BMI, systolic, or diastolic BP.

结论：补充左旋肉碱不会显着改变和改善血脂水平，包括TG，TC，HDL，LDL和VLDL水平。此外，它对BMI，收缩压或舒张压没有显着影响。