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Compass Psychological Support Model for COMP360 Psilocybin Treatment of Serious Mental Health Conditions.,American Journal of Psychiatry

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2025-05-08 03:02

Compass Psychological Support Model for COMP360 Psilocybin Treatment of Serious Mental Health Conditions.
American Journal of Psychiatry ( IF 15.1 ) Pub Date : 2025-01-01 , DOI: 10.1176/appi.ajp.20230884
Namik Kirlić 1 , Molly Lennard-Jones 1 , Merve Atli 1 , Ekaterina Malievskaia 1 , Nadav L Modlin 1 , Stephanie Knatz Peck 1 , Alice Gaillard 1 , Guy M Goodwin 1 , Don Koelpin 1

The psychedelic experience can be challenging. There is a need for a structured framework for providing psychological support to individuals with mental health conditions receiving investigational psilocybin treatment. The primary benefit of such a framework is to support a safe and meaningful psilocybin experience. It also enables future research on the facets of psychological support and/or psychotherapy that most optimally complement psilocybin treatment. The authors describe the Compass Psychological Support Model (CPSM), currently used to support participants with treatment-resistant depression in Compass-sponsored clinical trials of investigational COMP360 psilocybin treatment. The authors also outline the therapist training, mentoring, and fidelity assessment programs they have developed to ensure the quality and consistency of the CPSM delivery.

中文翻译：

COMP360裸盖菇素治疗严重心理健康状况的指南针心理支持模型。

迷幻体验可能具有挑战性。需要一个结构化的框架，为接受研究性裸盖菇素治疗的心理健康问题个体提供心理支持。这种框架的主要好处是支持安全且有意义的裸盖菇素体验。它还使未来对心理支持和/或心理治疗方面的研究成为可能，这些方面最有效地补充了裸盖菇素治疗。作者描述了 Compass 心理支持模型（CPSM），该模型目前用于在 Compass 赞助的研究性COMP360裸盖菇素治疗临床试验中支持难治性抑郁症参与者。作者还概述了他们为确保 CPSM 交付的质量和一致性而制定的治疗师培训、指导和保真度评估计划。

更新日期：2025-01-01