首页 > 资讯 > 尿液中的烷基间苯二酚代谢物是全谷物小麦和黑麦摄入量的生物标志物，与肝脏

尿液中的烷基间苯二酚代谢物是全谷物小麦和黑麦摄入量的生物标志物，与肝脏

泰然健康网
2025-05-08 21:47

尿液中的烷基间苯二酚代谢物是全谷物小麦和黑麦摄入量的生物标志物，与肝脏脂肪和其他脂肪测量值相关。

Zisuo Sun, Yaling Shao, Xiaoyu Zhang, Zhihao Zhou, Shu Ye, Mengfei Liu, Yaning Lv, Shaoyu Xie, Hongjun Cao, Zhuang Zhang and Wanshui Yang

摘要

目的：利用膳食生物标志物来调查全谷物摄入量与肥胖风险之间关系的流行病学研究并不多见。我们评估了尿液中烷基间苯二酚代谢物（包括 3-(3,5-二羟基苯基)-1-丙酸 (DHPPA) 和 3,5-二羟基苯甲酸 (DHBA)）、全谷物小麦和黑麦摄入量的生物标志物与身体脂肪测量值之间的关联。研究方法我们测量了中国霍山 306 名社区成年人的尿液中 DHPPA 和 DHBA 的排泄量、体重、身高、腰围和臀围。一年后，我们还测量了肝脏脂肪堆积（用受控衰减参数（CAP）表示）和其他身体成分。多元调整线性模型和线性混合效应模型分别用于分析单次测量和重复测量。结果显示尿液中 DHPPA 水平每增加 1 μg g-1 肌酐，体重、体重指数 (BMI)、体脂量 (BFM) 和内脏脂肪水平 (VFL) 分别下降 0.21%、0.23%、3.64% 和 4.80%（均 P < 0.05）。较高的 DHBA 水平与 CAP 成反比（肌酐每增加 1 μg g-1 的百分比差异：-1.98%，P < 0.05）。尿液中烷基间苯二酚总代谢物（DHPPA + DHBA）水平较高与体重、体重指数（BMI）、BFM、VFL 和 CAP 较低相关，每 1 μg g-1 肌酐增量的百分比差异分别为-0.27%、-0.27%、-3.79%、-5.12% 和 -2.24%（所有 P 均 < 0.05）。结论我们的研究结果表明，全谷物小麦和黑麦的摄入量（通过尿液中的 DHPPA 和 DHBA 反映）与肝脏脂肪和其他脂肪指标有良好的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

Urinary alkylresorcinol metabolites, biomarkers of whole grain wheat and rye intake, are beneficially associated with liver fat and other fat measures†

Aims: Epidemiological studies that use dietary biomarkers to investigate the association between whole grain intake and the risk of obesity are sparse. We assessed the association between urinary alkylresorcinol metabolites including 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenzoic acid (DHBA), biomarkers of whole grain wheat and rye intake, and body fat measures. Methods: We measured urinary excretion of DHPPA and DHBA, body weight, height, and circumferences of the waist and hip at the baseline and again after 1-year in a representative sample of 306 community-dwelling adults in Huoshan, China. We also measured liver fat accumulation [indicated by the controlled attenuation parameter (CAP)] and other body composition after 1 year. Multivariate-adjusted linear models and linear mixed-effects models were used to analyze single measurement and repeated measurements, respectively. Results: Each 1 μg g−1 creatinine increase in urinary DHPPA levels was associated with 0.21%, 0.23%, 3.64%, and 4.80% decrease in body weight, body mass index (BMI), body fat mass (BFM) and visceral fat level (VFL), respectively (all P < 0.05). Higher DHBA levels were inversely associated with CAP (percentage difference per 1 μg g−1 creatinine increment: −1.98%, P < 0.05). Higher total urinary alkylresorcinol metabolite (DHPPA + DHBA) levels were associated with lower body weight, BMI, BFM, VFL, and CAP, with the percentage differences per 1 μg g−1 creatinine increment of −0.27%, −0.27%, −3.79%, −5.12%, and −2.24%, respectively (all P < 0.05). Conclusions: Our findings suggest that the intake of whole grain wheat and rye, reflected by urinary DHPPA and DHBA, is favorably associated with liver fat and other fat measures.