A pH

泰然健康网
2025-08-03 00:17

Postoperative pain, as a common and significant healthcare issue, has always been the focus of attention in the field of anesthesia for its control and treatment. In the present study, a pH-responsive microneedle (MN) patch is developed for sustained incisional analgesia after surgery. The MN patch has a 10 × 10 MN array within 0.5 cm2 area, and each MN features a complete core-shell structure, with a needle height of ≈850 µm. Upon application, the MNs fully implant in the skin within 15 min due to the rapid dissolution of the water-soluble backing layer. The acidic microenvironment at the surgical site (pH 6.8–7.0) interacts with the pH-reactive medium in the MN shell, triggering the shell rupture. This process enables the smooth release of encapsulated local anesthetic drug (Ropivacaine, Rop) microcrystals, extending local anesthesia duration to over 72 h at a drug concentration of 100 mg mL−1. Additionally, the MN patch intelligently modulates drug release based on the postoperative pain behavior, which correlates with the pH value of the surgical incision microenvironment. This responsive feature results in a prolonged and personalized analgesic effect, addressing the limitations of existing invasive treatments in postoperative pain management.

中文翻译：

具有自我监测能力的 pH 响应核壳微针贴片，可实现局部长效镇痛

术后疼痛作为常见且重要的健康问题，其控制和治疗一直是麻醉领域关注的焦点。在本研究中，开发了一种 pH 响应型微针 (MN) 贴片，用于手术后持续切口镇痛。MN贴片在0.5 cm 2面积内具有10 × 10 MN阵列，每个MN具有完整的核壳结构，针高约850 µm。使用后，由于水溶性背衬层的快速溶解，MN 在 15 分钟内完全植入皮肤。手术部位的酸性微环境（pH 6.8-7.0）与 MN 壳中的 pH 反应介质相互作用，引发壳破裂。该过程使得封装的局部麻醉药物（罗哌卡因，Rop）微晶能够顺利释放，在药物浓度为100 mg mL -1时将局部麻醉持续时间延长至72 h以上。此外，MN 贴片根据术后疼痛行为智能调节药物释放，这与手术切口微环境的 pH 值相关。这种响应特性可产生持久且个性化的镇痛效果，解决了术后疼痛管理中现有侵入性治疗的局限性。