双酚A对女性生殖功能损伤及药物干预的研究进展
摘要：
双酚A（bisphenol A，BPA）是一种广泛存在于环境中的有机化合物，可干扰机体正常的新陈代谢，参与多种疾病的发生、发展。高剂量BPA暴露对生殖系统具有急性毒性作用；长期BPA暴露对生殖系统损伤更为显著，甚至可以产生跨代效应，影响后代的生长发育。BPA通过多种机制途径损伤女性生殖功能，降低女性生育力，因此，开发相关药物来缓解此种不良反应显得尤为重要。综述BPA对女性生殖系统的损伤，并介绍抗氧化剂、益生菌、维生素及中药对缓解BPA生殖损伤作用的研究进展，但相关药物在临床上的应用还需要循证医学证据支持。
关键词: 环境污染物, 内分泌干扰物, 女性, 生殖健康, 药物疗法, 双酚A
Abstract:
Bisphenol A (BPA) as an organic compound widely existing in the environment can interfere with the normal metabolism of the body and participate in the occurrence and development of a variety of diseases. High dose BPA exposure has an acute toxic effect on the reproductive system. Long-term exposure to BPA has more significant damage to the reproductive system, and can even produce intergenerational effects, affecting the growth and development of offspring. BPA damages female reproductive function and reduces female fertility through a variety of mechanisms. Therefore, it is particularly important to develop related drugs to alleviate this adverse reaction. This paper reviews the effects of BPA on female reproductive system, and introduces the research progress of antioxidants, probiotics, vitamins and traditional Chinese medicine on alleviating the effects of BPA on reproductive system. However, the clinical application of related drugs still needs the support of evidence-based medical evidence.
Key words: Environmental pollutants, Endocrine disruptors, Femininity, Reproductive health, Drug therapy, Bisphenol A
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