首页 > 资讯 > 运动干预对睡眠障碍的影响及作用机制研究进展

运动干预对睡眠障碍的影响及作用机制研究进展

摘要:

睡眠障碍严重影响人们的身心健康,已成为现代社会人们普遍关注的问题。研究表明,急性运动干预和长期规律性运动干预均可改善紊乱的睡眠结构,使各期睡眠时长和比例趋于正常。运动干预还能对睡眠期间的内分泌功能、代谢功能、免疫应答、自主神经系统和心脏功能产生积极影响,是改善睡眠障碍的一种非药物治疗手段。运动干预的类型(有氧运动、抗阻运动、身心运动)是运动干预方案的调节变量之一,不同类型的运动改善睡眠障碍的机制存在差异。运动量、运动强度是运动干预方案的另一调节变量,针对个体可能存在改善睡眠障碍最佳的运动量和运动强度。在不同时间段实施的运动干预也会对睡眠障碍造成不同程度的影响,目前在改善睡眠质量最佳运动时间段方面尚未形成共识。本文从表观遗传、过度觉醒、昼夜节律、体温调节等4个方面总结了运动改善睡眠障碍的作用机制,并讨论了目前该领域的研究不足和研究展望,为睡眠障碍运动处方的制定提供理论依据。

关键词: 运动干预  /  睡眠障碍  /  机制  /  综述  

Abstract:

Sleep disorders, a common concern in modern society, seriously affect people's physical and mental health. Reported findings suggest that both acute exercise intervention and long-term regular exercise intervention can improve the disrupted sleep structure and normalize the duration and proportion of the different phases of sleep. Moreover, exercise intervention has a positive effect on the endocrine functions, the metabolic functions, the immune response, the autonomic nervous system, and cardiac functions during sleep. It is a non-medicative therapeutic strategy for improving sleep disorders. The specific type of exercise intervention (aerobic exercise, resistance exercise, or meditative movement) adopted is one of the moderating variables of exercise intervention programs. Different types of exercise improve sleep disorders by way of different mechanisms. Exercise volume and intensity are another moderating variable of exercise intervention programs. The optimal amount and intensity of exercise for different individuals to improve sleep disorders may vary. Exercise interventions implemented at the different times throughout a day can also have varying degrees of impact on sleep disorders and there is no consensus on the optimal exercise time for improving sleep quality at present. Herein, we summarized the mechanisms by which exercise intervention improves sleep disorders from four perspectives, including epigenetics, hyperarousal, human circadian rhythm, and body temperature regulation. In addition, we discussed the current gaps and prospects of research in this field, aiming to provide a theoretical basis for the development of exercise prescriptions for sleep disorders.

[1] 任志洪, 谢菲, 余香莲, 等. 失眠的自助式认知行为治疗元分析: 疗效、影响因素及证据评价. 心理科学进展,2016,24(2): 173–195. doi: 10.3724/SP.J.1042.2016.00173.

REN Z H, XIE F, YU X L, et al. A meta-analysis of self-help cognitive behavioral therapy for insomnia: Efficacy, influential factors and the quality of evidence. Adv Psychol Sci,2016,24(2): 173–195. doi: 10.3724/SP.J.1042.2016.00173.

[2] 王俊秀, 张衍, 张跃, 等. 中国睡眠研究报告2023. 北京: 社会科学文献出版社, 2023: 13-33.

WANG J X, ZHANG Y, ZHANG Y, et al. Chinese Sleep Research Report 2023. Beijing: Social Sciences Academic Press, 2023: 13–33.

[3]

SO B C L, KWOK S C, LEE P H. Effect of aquatic exercise on sleep efficiency of adults with chronic musculoskeletal pain. J Phys Act Health,2021,18(9): 1037–1045. doi: 10.1123/jpah.2020-0476.

[4]

Da SILVA R P, MARTINEZ D, URIBE RAMOS J M, et al. The effects of resistance exercise on obstructive sleep apnea severity and body water content in older adults: a randomized controlled trial. Sleep Med,2022,95(8): 37–46. doi: 10.1016/j.sleep.2022.04.014.

[5]

HASAN F, TU YK, LIN C M, et al. Comparative efficacy of exercise regimens on sleep quality in older adults: a systematic review and network meta-analysis. Sleep Med Rev,2022,27(65): 1–7. doi: 10.1016/j.smrv.2022.101673.

[6] 李国平, 王正珍, 郝跃峰, 等. 运动处方中国专家共识(2023). 中国运动医学杂志,2023,42(1): 3–13. doi: 10.16038/j.1000-6710.2023.01.012.

LI G P, WANG Z Z, HAO Y F, et al. Chinese Expert Consensus on Exercise Prescription (2023). Chin J Sports Med,2023,42(1): 3–13. doi: 10.16038/j.1000-6710.2023.01.012.

[7]

CHENNAOUI M, ARNAL P J, SAUVET F, et al. Sleep and exercise: a reciprocal issue. Sleep Med Rev,2015,20(4): 59–72. doi: 10.1016/j.smrv.2014.06.008.

[8] 王宝森, 李婷文. 不同运动形式对老年人睡眠质量的影响. 中国老年学杂志,2020,40(7): 1465–1469. doi: 10.3969/j.issn.1005-9202.2020.07.037.

WANG B S, LI T W. Effect of different exercise forms on sleep quality of the elderly. Chin J Gerontol,2020,40(7): 1465–1469. doi: 10.3969/j.issn.1005-9202.2020.07.037.

[9]

KALAK N, GERBER M, KIROV R, et al. Daily morning running for 3 weeks improved sleep and psychological functioning in healthy adolescents compared with controls. Adolesc Health,2012,51(6): 615–622. doi: 10.1016/j.jadohealth.2012.02.020.

[10]

BLANCO-CENTURION C A, SHIROMANI P J. Beneficial effects of regular exercise on sleep in old F344 rats. Neurobiol Aging,2006,27(12): 1859–1869. doi: 10.1016/j.neurobiolaging.2005.10.009.

[11] 胡亮, 韩雨晴. 运动抗抑郁的神经生物学机制研究新进展. 陕西师范大学学报(自然科学版),2019,47(3): 9–20. doi: 10.15983/j.cnki.jsnu.2019.03.232.

HU L, HAN Y Q. Research progress on the neurobiological mechanism of the antidepressant effects of exercise. J Shanxi Norm Univ (Nat Sci Edit),2019,47(3): 9–20. doi: 10.15983/j.cnki.jsnu.2019.03.232.

[12]

TUCKOW A P, RARICK K R, KRAEMER W J, et al. Nocturnal growth hormone secretory dynamics are altered after resistance exercise: deconvolution analysis of 12-hour immunofunctional and immunoreactive isoforms. Am J Physiol Regul Integr Comp Physiol,2006,291(6): 1749–1755. doi: 10.1152/ajpregu.00854.2005.

[13]

CREWTHER B T, COOK C, CARDINALE M, et al. Two emerging concepts for elite athletes: the short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones. Sports Med,2011,41(2): 103–123. doi: 10.2165/11539170-000000000-00000.

[14]

CHEN P, BAYLIN A, LEE J, et al. The association between sleep duration and sleep timing and insulin resistance among adolescents in Mexico City. J Adolesc Health,2021,69(1): 57–63. doi: 10.1016/j.jadohealth.2020.10.012.

[15]

FENTON S, BURROWS T L, COLLINS C E, et al. Efficacy of a multi-component m-health diet, physical activity, and sleep intervention on dietary intake in adults with overweight and obesity: a randomised controlled trial. Nutrients,2021,13(7): 1–17. doi: 10.3390/nu13072468.

[16] 岳宇娇, 徐平. 睡眠剥夺相关血液生物学指标研究进展. 中国神经精神疾病杂志,2020,46(6): 376–379. doi: 10.3969/j.issn.1002-0152.2020.06.015.

YUE Y J, XU P. Research progress on blood biological indicators related to sleep deprivation. Chin J Nerv Ment Dis,2020,46(6): 376–379. doi: 10.3969/j.issn.1002-0152.2020.06.015.

[17]

SANTOS R V, TUFIK S, De MELLO M T. Exercise, sleep and cytokines: is there a relation. Sleep Med Rev,2007,11(3): 231–239. doi: 10.1016/j.smrv.2007.03.003.

[18]

SCHEFFER D D L, LATINI A. Exercise-induced immune system response: anti-inflammatory status on peripheral and central organs. Biochim Biophys Acta Mol Basis Dis,2020,1866(10): 1–15. doi: 10.1016/j.bbadis.2020.165823.

[19]

SHAW D M, MERIEN F, BRAAKHUIS A, et al. T-cells and their cytokine production: the anti-inflammatory and immunosuppressive effects of strenuous exercise. Cytokine,2018,104(3): 136–142. doi: 10.1016/j.cyto.2017.10.001.

[20] 张震, 王冬慧, 孙娜, 等. 失眠伴焦虑患者的脑功能及心率变异性分析. 首都医科大学学报,2021,42(3): 464–469. doi: 10.3969/j.issn.1006-7795.2021.03.021.

ZHAGN Z, WANG D H, SUN N, et al. Analysis of brain function and heart rate variability in insomnia patients with anxiety. J Cap Med Univ,2021,42(3): 464–469. doi: 10.3969/j.issn.1006-7795.2021.03.021.

[21]

KING A C, PRUITT L A, WOO S, et al. Effects of moderate-intensity exercise on polysomnographic and subjective sleep quality in older adults with mild to moderate sleep complaints. J Gerontol A Biol Sci Med Sci,2008,63(9): 997–1004. doi: 10.1093/gerona/63.9.997.

[22]

RUBIO-ARIAS J Á, MARÍN-CASCALES E, RAMOS-CAMPO D J, et al. Effect of exercise on sleep quality and insomnia in middle-aged women: a systematic review and meta-analysis of randomized controlled trials. Maturitas,2017,100(1): 49–56. doi: 10.1016/j.maturitas.2017.04.003.

[23] 李莹雪, 葛义俊, 孔晓艺, 等. 慢性失眠患者血清神经营养因子改变及其与睡眠质量和认知功能的关系. 中华神经科杂志,2020,53(2): 85–90. doi: 10.3760/cma.j.issn.1006-7876.2020.02.002.

LI Y X, GE Y J, SUN X Y, et al. Changed serum levels of neurotrophic factors and their correlations with sleep and cognition in patients with chronic insomnia disorder. Chin J Psychiatry,2020,53(2): 85–90. doi: 10.3760/cma.j.issn.1006-7876.2020.02.002.

[24]

WHITWORTH J W, NOSRAT S, SANTABARBARA N J, et al. High intensity resistance training improves sleep quality and anxiety in individuals who screen positive for posttraumatic stress disorder: a randomized controlled feasibility trial. Ment Health Phys Act,2019,16(3): 43–49. doi: 10.1016/j.mhpa.2019.04.001.

[25]

SANER N J, BISHOP D J, BARTLETT J D. Is exercise a viable therapeutic intervention to mitigate mitochondrial dysfunction and insulin resistance induced by sleep loss. Sleep Med Rev,2018,37(1): 60–68. doi: 10.1016/j.smrv.2017.01.001.

[26]

SEVERINSEN M C K, PEDERSEN B K. Muscle-organ crosstalk: the emerging roles of myokines. Endocr Rev,2020,41(4): 594–609. doi: 10.1210/endrev/bnaa016.

[27]

IRWIN M R, OLMSTEAD R, CARRILLO C, et al. Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep,2014,37(9): 1543–1552. doi: 10.5665/sleep.4008.

[28]

WANG F, EUN-KYOUNG LEE O, FENG F, et al. The effect of meditative movement on sleep quality: a systematic review. Sleep Med Rev,2016,30(12): 43–52. doi: 10.1016/j.smrv.2015.12.001.

[29] 王骏昇, 孟皎, 郭子肈, 等. 身心锻炼对睡眠质量影响的系统综述. 中国康复理论与实践,2023,29(2): 205–213. doi: 10.3969/j.issn.1006-9771.2023.02.009.

WANG J S, MENG J, GUO Z Z, et al. Effects of mind-body exercise on sleep quality: a systematic review. Chin J Rehabil Theory Pract,2023,29(2): 205–213. doi: 10.3969/j.issn.1006-9771.2023.02.009.

[30] 侯江涛, 郑鸿铭, 严梓萁, 等. 八段锦干预失眠症患者疗效的Meta分析. 广州体育学院学报,2022,42(2): 59–69. doi: 10.13830/j.cnki.cn44-1129/g8.2022.02.008.

HOU J T, ZHENG H M, YAN Z Q, et al. Meta-analysis of the efficacy of baduanjin exercise on patients with sleep initiation and maintenance disorders. J Guangzhou Sport Univ,2022,42(2): 59–69. doi: 10.13830/j.cnki.cn44-1129/g8.2022.02.008.

[31] 李良, 曹烃, 钟建伟, 等. 《美国人身体活动指南第2版(2018)》解读及启示. 体育学刊,2019,26(5): 96–102. doi: 10.16237/j.cnki.cn44-1404/g8.2019.05.011.

LI L, CAO T, ZHONG J W, et al. An interpretation of and inspirations from the American Physical Activity Guide 2nd Edition (2018). J Phys Educ,2019,26(5): 96–102. doi: 10.16237/j.cnki.cn44-1404/g8.2019.05.011.

[32]

AN K Y, MORIELLI A R, KANG D W, et al. Effects of exercise dose and type during breast cancer chemotherapy on longer-term patient-reported outcomes and health-related fitness: a randomized controlled trial. Int J Cancer,2020,146(1): 150–160. doi: 10.1002/ijc.32493.

[33] 李振瑞, 占超, 郭超阳, 等. 预防老年人跌倒的最佳太极拳运动量的Meta分析. 时珍国医国药,2021,32(2): 504–509. doi: 10.3969/j.issn.1008-0805.2021.02.75.

LI Z R, ZHAN C, GUO C Y, et al. Meta analysis of the optimal amount of Tai Chi exercise for preventing falls in the elderly. Lishizhen Med Mater Med Res,2021,32(2): 504–509. doi: 10.3969/j.issn.1008-0805.2021.02.75.

[34]

KLINE C E, SUI X, HALL M H, et al. Dose-response effects of exercise training on the subjective sleep quality of postmenopausal women: exploratory analyses of a randomised controlled trial. BMJ Open,2012,2(4): 1–9. doi: 10.1136/bmjopen-2012-001044.

[35]

BUMAN M P, KING A C. Exercise as a treatment to enhance sleep. Am J Lifestyle Med,2010,4(6): 500–514. doi: 10.1177/1559827610375532.

[36]

STUTZ J, EIHOLZER R, SPENGLER C M. Effects of evening exercise on sleep in healthy participants: a systematic review and meta-analysis. Sports Med,2019,49(2): 269–287. doi: 10.1007/s40279-018-1015-0.

[37]

BENLOUCIF S, ORBETA L, ORTIZ R, et al. Morning or evening activity improves neuropsychological performance and subjective sleep quality in older adults. Sleep,2004,27(1): 1542–1551. doi: 10.1093/sleep/27.8.1542.

[38]

FRIMPONG E, MOGRASS M, ZVIONOW T, et al. The effects of evening high-intensity exercise on sleep in healthy adults: a systematic review and meta-analysis. Sleep Med Rev,2021,60(5): 1–16. doi: 10.1016/j.smrv.2021.101535.

[39] 石海旺, 李婕, 吴冲云, 等. 运动改善药物依赖者免疫功能障碍的研究进展. 中国体育科技,2021,57(6): 38–45. doi: 10.16470/j.csst.2021059.

SHI H W, LI J, WU C Y, et al. Research on improving immune dysfunction in drug-dependent patients by exercise. China Sport Sci Technol,2021,57(6): 38–45. doi: 10.16470/j.csst.2021059.

[40]

YUE T, LIU X, GAO Q, et al. Different intensities of evening exercise on sleep in healthy adults: a systematic review and network meta-analysis. Nat Sci Sleep,2022,14(14): 2157–2177. doi: 10.2147/NSS.S388863.

[41]

CORTESE R. Epigenetics of sleep disorders: an emerging field in diagnosis and therapeutics. Diagnostics (Basel),2021,11(5): 1–4. doi: 10.3390/diagnostics11050851.

[42]

CEDERNAES J, SCHONKE M, WESTHOLM J O, et al. Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans. Sci Adv,2018,4(8): 1–15. doi: 10.1126/sciadv.aar8590.

[43]

PALAGINI L, GEOFFROY P A, GEHRMAN P R, et al. Potential genetic and epigenetic mechanisms in insomnia: a systematic review. J Sleep Res,2023,32(6): 13868–13878. doi: 10.1111/jsr.13868.

[44]

PALAGINI L, BIBER K, RIEMANN D. The genetics of insomnia-evidence for epigenetic mechanisms. Sleep Med Rev,2014,18(3): 225–235. doi: 10.1016/j.smrv.2013.05.002.

[45]

BONNET M H, ARAND D L. Hyperarousal and insomnia: state of the science. Sleep Med Rev,2010,14(1): 9–15. doi: 10.1016/j.smrv.2009.05.002.

[46]

Van SOMEREN E J W. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev,2021,101(3): 995–1046. doi: 10.1152/physrev.00046.2019.

[47] 赵文瑞, 李陈渝, 陈军君, 等. 失眠障碍与过度觉醒: 来自静息态脑电和睡眠脑电的证据. 中国科学:生命科学,2020,50(3): 270–286. doi: 10.1360/SSV-2019-0234.

ZHAO W R, LI C Y, CHEN J J, et al. Insomnia disorder and hyperarousal: evidence from resting-state and sleeping EEG. Sci Sin Vitae,2020,50(3): 270–286. doi: 10.1360/SSV-2019-0234.

[48] 杨栋. 2种不同运动方式对原发性失眠患者睡眠质量的干预效果. 上海体育学院学报,2020,44(11): 38–43. doi: 10.16099/j.sus.2020.11.005.

YNAG D. Intervention Effect of Two Different Exercise Modes on Sleep Ouality of Patients with Primary Insomnia. J Shanghai Univ Sport,2020,44(11): 38–43. doi: 10.16099/j.sus.2020.11.005.

[49]

MEYER N, HARVEY A G, LOCKLEY S W, et al. Circadian rhythms and disorders of the timing of sleep. Lancet,2022,400(10357): 1061–1078. doi: 10.1016/S0140-6736(22)00877-7.

[50] 彭景, 任保印, 张荷等. 生物钟紊乱防治策略的研究进展. 生理学报,2023,75(2): 279–290. doi: 10.13294/j.aps.2023.0021.

PENG J, REN B Y, ZHANG H, et al. Research progress in control strategies of biological clock disorder. Acta Physiologica Sinica,2023,75(2): 279–290. doi: 10.13294/j.aps.2023.0021.

[51] 黄卓淳, 漆正堂, 刘微娜. 运动与褪黑素抗抑郁的作用、机制以及联合策略研究进展. 中国体育科技,2020,56(2): 3–14. doi: 10.16470/j.csst.2019085.

HUANG Z C, QI Z T, LIU W N. Research progress on the antidepressant effect, mechanism and joint strategy of exercise and melatonin. China Sport Sci Technol,2020,56(2): 3–14. doi: 10.16470/j.csst.2019085.

[52] 刘恒旭, 陈佩杰, 卢文云, 等. 体育锻炼: 介导骨骼肌昼夜节律分子钟的时间线索. 上海体育学院学报,2022,46(6): 94–106. doi: 10.16099/j.sus.2021.04.30.0002.

LIU H X, CHEN P J, LU W Y, et al. Physical exercise: the time clue that mediates the molecular clock of skeletal muscle circadian rhythm. J Shanghai Univ Sport,2022,46(6): 94–106. doi: 10.16099/j.sus.2021.04.30.0002.

[53]

REID K J, KRÄUCHI K, GRIMALDI D, et al. Effects of manipulating body temperature on sleep in postmenopausal women. Sleep Med,2021,81(5): 109–115. doi: 10.1016/j.sleep.2021.01.064.

[54]

LACK L C, GRADISAR M, Van SOMEREN E J, et al. The relationship between insomnia and body temperatures. Sleep Med Rev,2008,12(4): 307–317. doi: 10.1016/j.smrv.2008.02.003.

[55]

MURPHY P J, CAMPBELL S S. Sex hormones, sleep, and core body temperature in older postmenopausal women. Sleep,2007,30(12): 1788–1794. doi: 10.1093/sleep/30.12.1788.

相关知识

丰富环境改善睡眠与认知障碍的作用及研究进展
孕妇睡眠障碍的影响因素研究
眩晕与睡眠障碍的研究进展
孕期睡眠障碍的流行病学研究进展
瑜伽对产前抑郁症干预作用及机制的研究进展
孕中期孕妇睡眠质量现状及影响因素研究进展
孕期睡眠相关营养因素的研究进展
健康|研究显示:广东省睡眠障碍患病率高于全国
睡眠障碍
睡眠影响大脑健康

网址: 运动干预对睡眠障碍的影响及作用机制研究进展 https://m.trfsz.com/newsview532294.html