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Research progress and potential mechanism of postbiotics in alleviating gastrointestinal diseases

[1] CHENG LK, O'GRADY G, DU P, EGBUJI JU, WINDSOR JA, PULLAN AJ. Gastrointestinal system[J]. Wiley Interdisciplinary Reviews Systems Biology and Medicine, 2010, 2(1): 65-79 DOI:10.1002/wsbm.19. [2] GOLDSTEIN AM, HOFSTRA RW, BURNS AJ. Building a brain in the gut: development of the enteric nervous system[J]. Clinical Genetics, 2013, 83(4): 307-316 DOI:10.1111/cge.12054. [3] LI JY, CHEN DW, YU B, HE J, ZHENG P, MAO XB, YU J, LUO JQ, TIAN G, HUANG ZQ, LUO YH. Fungi in gastrointestinal tracts of human and mice: from community to functions[J]. Microbial Ecology, 2018, 75(4): 821-829 DOI:10.1007/s00248-017-1105-9. [4] THURSBY E, JUGE N. Introduction to the human gut microbiota[J]. The Biochemical Journal, 2017, 474(11): 1823-1836 DOI:10.1042/BCJ20160510. [5] COLLINS SM, SURETTE M, BERCIK P. The interplay between the intestinal microbiota and the brain[J]. Nature Reviews Microbiology, 2012, 10(11): 735-742 DOI:10.1038/nrmicro2876. [6] POWER SE, O'TOOLE PW, STANTON C, ROSS RP, FITZGERALD GF. Intestinal microbiota, diet and health[J]. The British Journal of Nutrition, 2014, 111(3): 387-402 DOI:10.1017/S0007114513002560. [7] JIN MC, QIAN ZY, YIN JY, XU WT, ZHOU X. The role of intestinal microbiota in cardiovascular disease[J]. Journal of Cellular and Molecular Medicine, 2019, 23(4): 2343-2350 DOI:10.1111/jcmm.14195. [8] SCARPELLINI E, RINNINELLA E, BASILICO M, COLOMIER E, RASETTI C, LARUSSA T, SANTORI P, ABENAVOLI L. From pre- and probiotics to post-biotics: a narrative review[J]. International Journal of Environmental Research and Public Health, 2021, 19(1): 37 DOI:10.3390/ijerph19010037. [9] IRRAZÁBAL T, BELCHEVA A, GIRARDIN SE, MARTIN A, PHILPOTT DJ. The multifaceted role of the intestinal microbiota in colon cancer[J]. Molecular Cell, 2014, 54(2): 309-320 DOI:10.1016/j.molcel.2014.03.039. [10] WINTER SE, LOPEZ CA, BÄUMLER AJ. The dynamics of gut-associated microbial communities during inflammation[J]. EMBO Reports, 2013, 14(4): 319-327 DOI:10.1038/embor.2013.27. [11] OJETTI V, GIGANTE G, AINORA ME, FIORE F, BARBARO F, GASBARRINI A. Microflora imbalance and gastrointestinal diseases[J]. Digestive and Liver Disease Supplements, 2009, 3(2): 35-39 DOI:10.1016/S1594-5804(09)60017-6. [12] SINGH R, ZOGG H, WEI L, BARTLETT A, GHOSHAL UC, RAJENDER S, RO S. Gut microbial dysbiosis in the pathogenesis of gastrointestinal dysmotility and metabolic disorders[J]. Journal of Neurogastroenterology and Motility, 2021, 27(1): 19-34 DOI:10.5056/jnm20149. [13] ZHANG M, YANG XJ. Effects of a high fat diet on intestinal microbiota and gastrointestinal diseases[J]. World Journal of Gastroenterology, 2016, 22(40): 8905-8909 DOI:10.3748/wjg.v22.i40.8905. [14] RIAZ RAJOKA MS, SHI JL, MEHWISH HM, ZHU J, LI Q, SHAO DY, HUANG QS, YANG H. Interaction between diet composition and gut microbiota and its impact on gastrointestinal tract health[J]. Food Science and Human Wellness, 2017, 6(3): 121-130 DOI:10.1016/j.fshw.2017.07.003. [15] GALLO A, PASSARO G, GASBARRINI A, LANDOLFI R, MONTALTO M. Modulation of microbiota as treatment for intestinal inflammatory disorders: an uptodate[J]. World Journal of Gastroenterology, 2016, 22(32): 7186-7202 DOI:10.3748/wjg.v22.i32.7186. [16] NIEDERWERDER MC. Fecal microbiota transplantation as a tool to treat and reduce susceptibility to disease in animals[J]. Veterinary Immunology and Immunopathology, 2018, 206: 65-72 DOI:10.1016/j.vetimm.2018.11.002. [17] HILL C, GUARNER F, REID G, GIBSON GR, MERENSTEIN DJ, POT B, MORELLI L, CANANI RB, FLINT HJ, SALMINEN S, CALDER PC, ELLEN SANDERS M. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic[J]. Nature Reviews Gastroenterology & Hepatology, 2014, 11(8): 506-514. [18] LIANG DF, WU F, ZHOU DX, TAN BZ, CHEN TT. Commercial probiotic products in public health: current status and potential limitations[J]. Critical Reviews in Food Science and Nutrition, 2023: 1-22. [19] ABBASI A, RAD AH, GHASEMPOUR Z, SABAHI S, KAFIL HS, HASANNEZHAD P, RAHBAR SAADAT Y, SHAHBAZI N. The biological activities of postbiotics in gastrointestinal disorders[J]. Critical Reviews in Food Science and Nutrition, 2022, 62(22): 5983-6004 DOI:10.1080/10408398.2021.1895061. [20] SALMINEN S, COLLADO MC, ENDO A, HILL C, LEBEER S, QUIGLEY EMM, ELLEN SANDERS M, SHAMIR R, SWANN JR, SZAJEWSKA H, VINDEROLA G. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics[J]. Nature Reviews Gastroenterology & Hepatology, 2021, 18(9): 649-667. [21] HOMAYOUNI RAD A, AGHEBATI MALEKI L, SAMADI KAFIL H, ABBASI A. Postbiotics: a novel strategy in food allergy treatment[J]. Critical Reviews in Food Science and Nutrition, 2021, 61(3): 492-499 DOI:10.1080/10408398.2020.1738333. [22] GAO J, LI YB, WAN Y, HU TT, LIU LT, YANG SJ, GONG ZL, ZENG Q, WEI Y, YANG WJ, ZENG ZJ, HE XL, HUANG SH, CAO H. A novel postbiotic from Lactobacillus rhamnosus GG with a beneficial effect on intestinal barrier function[J]. Frontiers in Microbiology, 2019, 10: 477 DOI:10.3389/fmicb.2019.00477. [23] DINU LD, AVRAM I, PELINESCU DR, VAMANU E. Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis[J]. Biomedicines, 2022, 10(10): 2392 DOI:10.3390/biomedicines10102392. [24] ZHANG T, ZHANG WQ, FENG CJ, KWOK LY, HE QW, SUN ZH. Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model[J]. Npj Science of Food, 2022, 6(1): 53 DOI:10.1038/s41538-022-00169-9. [25] HE XL, ZENG Q, PUTHIYAKUNNON S, ZENG ZJ, YANG WJ, QIU JW, DU L, BODDU S, WU TW, CAI DX, HUANG SH, CAO H. Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense[J]. Scientific Reports, 2017, 7(1): 43305 DOI:10.1038/srep43305. [26] ZHANG SS, WANG RX, LI DY, ZHAO LQ, ZHU LX. Role of gut microbiota in functional constipation[J]. Gastroenterology Report, 2021, 9(5): 392-401 DOI:10.1093/gastro/goab035. [27] ZHAO YM, LIU QJ, HOU YM, ZHAO YQ. Alleviating effects of gut micro-ecologically regulatory treatments on mice with constipation[J]. Frontiers in Microbiology, 2022, 13: 956438 DOI:10.3389/fmicb.2022.956438. [28] PARK SA, LEE GH, HOANG TH, LEE HY, KANG IY, CHUNG MJ, JIN JS, CHAE HJ. Heat-inactivated Lactobacillus plantarum nF1 promotes intestinal health in Loperamide-induced constipation rats[J]. PLoS One, 2021, 16(4): e0250354 DOI:10.1371/journal.pone.0250354. [29] GE XL, ZHAO W, DING C, TIAN HL, XU LZ, WANG HK, NI L, JIANG J, GONG JF, ZHU WM, ZHU MS, LI N. Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility[J]. Scientific Reports, 2017, 7: 441 DOI:10.1038/s41598-017-00612-y. [30] DE VRESE M, OFFICK B. Probiotics and prebiotics: effects on diarrhea[J]. Bioactive Foods in Promoting Health, 2010: 205-227. [31] XU XY, ELIAS DUARTE M, KIM SW. Postbiotic effects of Lactobacillus fermentate on intestinal health, mucosa-associated microbiota, and growth efficiency of nursery pigs challenged with F18+ Escherichia coli[J]. Journal of Animal Science, 2022, 100(8): skac210 DOI:10.1093/jas/skac210. [32] HO HH, KUO YW, CHEN JF, HUANG YF, LIU CR, LIN JH, CHEN CW. The postbiotics, totipro PE0401, and probiotic mixture, PF1001, modulate the gut microbiota and ameliorate diarrhea in weaning piglets[J]. Biomedical Journal of Scientific & Technical Research, 2020, 28(1): 21194-21205. [33] MORALES-FERRÉ C, AZAGRA-BORONAT I, MASSOT-CLADERA M, TIMS S, KNIPPING K, GARSSEN J, KNOL J, FRANCH À, CASTELL M, PÉREZ-CANO FJ, RODRÍGUEZ-LAGUNAS MJ. Preventive effect of a postbiotic and prebiotic mixture in a rat model of early life Rotavirus induced-diarrhea[J]. Nutrients, 2022, 14(6): 1163 DOI:10.3390/nu14061163. [34] WANG HY, ZHAO XJ, CUI XF, WANG MF, JIAO CH, LI JJ, YANG Y, LI Y, ZHANG HJ. A pilot study of clinical evaluation and formation mechanism of irritable bowel syndrome-like symptoms in inflammatory bowel disease patients in remission[J]. Journal of Neurogastroenterology and Motility, 2021, 27(4): 612-625 DOI:10.5056/jnm20151. [35] ALTOMARE A, Di ROSA C, IMPERIA E, EMERENZIANI S, CICALA M, GUARINO MPL. Diarrhea predominant-irritable bowel syndrome (IBS-D): effects of different nutritional patterns on intestinal dysbiosis and symptoms[J]. Nutrients, 2021, 13(5): 1506 DOI:10.3390/nu13051506. [36] SEONG G, LEE S, MIN YW, JANG YS, KIM HS, KIM EJ, PARK SY, KIM CH, CHANG DK. Effect of heat-killed Lactobacillus casei DKGF7 on a rat model of irritable bowel syndrome[J]. Nutrients, 2021, 13(2): 568 DOI:10.3390/nu13020568. [37] WANG YM, GE XZ, WANG WQ, WANG T, CAO HL, WANG BL, WANG BM. Lactobacillus rhamnosusGG supernatant upregulates serotonin transporter expression in intestinal epithelial cells and mice intestinal tissues[J]. Neurogastroenterology & Motility, 2015, 27(9): 1239-1248. [38] RUSSO E, GIUDICI F, FIORINDI C, FICARI F, SCARINGI S, AMEDEI A. Immunomodulating activity and therapeutic effects of short chain fatty acids and tryptophan post-biotics in inflammatory bowel disease[J]. Frontiers in Immunology, 2019, 10: 2754 DOI:10.3389/fimmu.2019.02754. [39] FENG CJ, ZHANG WQ, ZHANG T, HE QW, KWOK LY, TAN Y, ZHANG HP. Heat-killed Bifidobacterium bifidum B1628 may alleviate dextran sulfate sodium-induced colitis in mice, and the anti-inflammatory effect is associated with gut microbiota modulation[J]. Nutrients, 2022, 14(24): 5233 DOI:10.3390/nu14245233. [40] CHANDHNI PR, PRADHAN D, SOWMYA K, GUPTA S, KADYAN S, CHOUDHARY R, GUPTA A, GULATI G, MALLAPPA RH, KAUSHIK JK, GROVER S. Ameliorative effect of surface proteins of probiotic lactobacilli in colitis mouse models[J]. Frontiers in Microbiology, 2021, 12: 679773 DOI:10.3389/fmicb.2021.679773. [41] KVAKOVA M, KAMLAROVA A, STOFILOVA J, BENETINOVA V, BERTKOVA I. Probiotics and postbiotics in colorectal cancer: Prevention and complementary therapy[J]. World Journal of Gastroenterology, 2022, 28(27): 3370-3382 DOI:10.3748/wjg.v28.i27.3370. [42] MA FL, SONG YL, SUN MY, WANG AR, JIANG SJ, MU GQ, TUO YF. Exopolysaccharide produced by Lactiplantibacillus plantarum-12 alleviates intestinal inflammation and colon cancer symptoms by modulating the gut microbiome and metabolites of C57BL/6 mice treated by azoxymethane/dextran sulfate sodium salt[J]. Foods, 2021, 10(12): 3060 DOI:10.3390/foods10123060. [43] SHARMA M, SHUKLA G. Administration of metabiotics extracted from probiotic Lactobacillus rhamnosus MD 14 inhibit experimental colorectal carcinogenesis by targeting Wnt/β-catenin pathway[J]. Frontiers in Oncology, 2020, 10: 746 DOI:10.3389/fonc.2020.00746. [44] SAWADA D, SUGAWARA T, ISHIDA Y, AIHARA K, AOKI Y, TAKEHARA I, TAKANO K, FUJIWARA S. Effect of continuous ingestion of a beverage prepared with Lactobacillus gasseri CP2305 inactivated by heat treatment on the regulation of intestinal function[J]. Food Research International, 2016, 79: 33-39 DOI:10.1016/j.foodres.2015.11.032. [45] SALAZAR-LINDO E, FIGUEROA-QUINTANILLA D, CACIANO MI, RETO-VALIENTE V, CHAUVIERE G, COLIN P. Effectiveness and safety of Lactobacillus LB in the treatment of mild acute diarrhea in children[J]. Journal of Pediatric Gastroenterology & Nutrition, 2007, 44(5): 571-576. [46] XIAO SD, ZHANG ZD, LU H, JIANG SH, LIU HY, WANG GS, XU GM, ZHANG ZB, LIN GJ, WANG GL. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea[J]. Advances in Therapy, 2003, 20(5): 253-260 DOI:10.1007/BF02849854. [47] ANDRESEN V, GSCHOSSMANN J, LAYER P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial[J]. The Lancet Gastroenterology & Hepatology, 2020, 5(7): 658-666. [48] TARRERIAS AL, COSTIL V, VICARI F, LÉTARD JC, ADENIS-LAMARRE P, AISÈNE A, BATISTELLI D, BONNAUD G, CARPENTIER S, DALBIÈS P, ECUER S, ETIENNE J, FANTOLI M, GRUNBERG B, LANNOY P, LAPUELLE J, MARGULIES A, NEUMEIER M, ROUILLON JM, SCHMETS L, et al. The effect of inactivated Lactobacillus LB fermented culture medium on symptom severity: observational investigation in 297 patients with diarrhea-predominant irritable bowel syndrome[J]. Digestive Diseases, 2011, 29(6): 588-591 DOI:10.1159/000332987. [49] IZUDDIN WI, LOH TC, FOO HL, SAMSUDIN AA, HUMAM AM. Postbiotic L. plantarum RG14 improves ruminal epithelium growth, immune status and upregulates the intestinal barrier function in post- weaning lambs[J]. Scientific Reports, 2019, 9: 9938 DOI:10.1038/s41598-019-46076-0. [50] ENGEVIK MA, LUK B, CHANG-GRAHAM AL, HALL A, HERRMANN B, RUAN W, ENDRES BT, SHI ZC, GAREY KW, HYSER JM, VERSALOVIC J. Bifidobacterium dentium fortifies the intestinal mucus layer via autophagy and calcium signaling pathways[J]. mBio, 2019, 10(3): e01087-e01019. [51] MOSCA A, TERESA ABREU Y ABREU A, GWEE KA, IANIRO G, TACK J, NGUYEN TVH, HILL C. The clinical evidence for postbiotics as microbial therapeutics[J]. Gut Microbes, 2022, 14(1): 2117508 DOI:10.1080/19490976.2022.2117508. [52] MAYORGAS A, DOTTI I, SALAS A. Microbial metabolites, postbiotics, and intestinal epithelial function[J]. Molecular Nutrition & Food Research, 2021, 65(5): e2000188. [53] ELISE GHEORGHE C, MARTIN JA, MANRIQUEZ FV, DINAN TG, CRYAN JF, CLARKE G. Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis[J]. Current Opinion in Pharmacology, 2019, 48: 137-145 DOI:10.1016/j.coph.2019.08.004. [54] SCOTT SA, FU JJ, CHANG PV. Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor[J]. Proceedings of the National Academy of Sciences, 2020, 117(32): 19376-19387 DOI:10.1073/pnas.2000047117. [55] VALLEJO-CORDOBA B, CASTRO-LÓPEZ C, GARCÍA HS, GONZÁLEZ-CÓRDOVA AF, HERNÁNDEZ-MENDOZA A. Postbiotics and paraprobiotics: A review of current evidence and emerging trends[J]. Advances in Food and Nutrition Research, 2020, 94: 1-34. [56] JASTRZĄB R, GRACZYK D, SIEDLECKI P. Molecular and cellular mechanisms influenced by postbiotics[J]. International Journal of Molecular Sciences, 2021, 22(24): 13475 DOI:10.3390/ijms222413475. [57] TEAME T, WANG AR, XIE MX, ZHANG Z, YANG YL, DING QW, GAO CC, OLSEN RE, RAN C, ZHOU ZG. Paraprobiotics and postbiotics of probiotic Lactobacilli, their positive effects on the host and action mechanisms: a review[J]. Frontiers in Nutrition, 2020, 7: 570344 DOI:10.3389/fnut.2020.570344. [58] MOTTA V, SOARES F, SUN T, PHILPOTT DJ. NOD-like receptors: versatile cytosolic sentinels[J]. Physiological Reviews, 2015, 95(1): 149-178 DOI:10.1152/physrev.00009.2014. [59] GEDDES K, MAGALHÃES JG, GIRARDIN SE. Unleashing the therapeutic potential of NOD-like receptors[J]. Nature Reviews Drug Discovery, 2009, 8(6): 465-479 DOI:10.1038/nrd2783. [60] WANG DJ. NOD1 and NOD2 are potential therapeutic targets for cancer immunotherapy[J]. Computational Intelligence and Neuroscience, 2022, 2022: 1-10. [61] THORAKKATTU P, KHANASHYAM AC, SHAH K, BABU KS, MUNDANAT AS, DELIEPHAN A, DEOKAR GS, SANTIVARANGKNA C, NIRMAL NP. Postbiotics: Current trends in food and pharmaceutical industry[J]. Foods, 2022, 11(19): 3094 DOI:10.3390/foods11193094. [62] LUCHNER M, REINKE S, MILICIC A. TLR agonists as vaccine adjuvants targeting cancer and infectious diseases[J]. Pharmaceutics, 2021, 13(2): 142 DOI:10.3390/pharmaceutics13020142. [63] YIN Q, FU TM, LI JX, WU H. Structural biology of innate immunity[J]. Annual Review of Immunology, 2015, 33: 393-416 DOI:10.1146/annurev-immunol-032414-112258. [64] SCHWANDNER R, DZIARSKI R, WESCHE H, ROTHE M, KIRSCHNING CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2[J]. Journal of Biological Chemistry, 1999, 274(25): 17406-17409 DOI:10.1074/jbc.274.25.17406. [65] GAO K, WANG C, LIU L, DOU XX, LIU JX, YUAN LJ, ZHANG WM, WANG HF. Immunomodulation and signaling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide[J]. Journal of Microbiology, Immunology and Infection, 2017, 50(5): 700-713 DOI:10.1016/j.jmii.2015.05.002. [66] XU W, CAO FW, ZHAO M, FU XY, YIN SY, SUN YJ, VALENCAK TG, REN D. Macrophage activation by exopolysaccharides from Streptococcus thermophilus fermented milk through TLRs-mediated NF-κB and MAPK pathways[J]. International Immunopharmacology, 2022, 108: 108875 DOI:10.1016/j.intimp.2022.108875. [67] LIN MY, DE ZOETE MR, VAN PUTTEN JPM, STRIJBIS K. Redirection of epithelial immune responses by short-chain fatty acids through inhibition of histone deacetylases[J]. Frontiers in Immunology, 2015, 6: 554. [68] AGHEBATI-MALEKI L, HASANNEZHAD P, ABBASI A, KHANI N. Antibacterial, antiviral, antioxidant, and anticancer activities of postbiotics: a review of mechanisms and therapeutic perspectives[J]. Biointerface Research in Applied Chemistry, 2021, 12(2): 2629-2645 DOI:10.33263/BRIAC122.26292645. [69] MANTZIARI A, SALMINEN S, SZAJEWSKA H, MALAGÓN-ROJAS JN. Postbiotics against pathogens commonly involved in pediatric infectious diseases[J]. Microorganisms, 2020, 8(10): 1510 DOI:10.3390/microorganisms8101510. [70] PUDDU A, SANGUINETI R, MONTECUCCO F, VIVIANI GL. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes[J]. Mediators of Inflammation, 2014, 2014: 162021. [71] JIMINEZ JA, UWIERA TC, ABBOTT DW, UWIERA RRE, DOUGLAS INGLIS G. Butyrate supplementation at high concentrations alters enteric bacterial communities and reduces intestinal inflammation in mice infected with Citrobacter rodentium[J]. mSphere, 2017, 2(4): e00243-e00217. [72] LEVY M, THAISS CA, ZEEVI D, DOHNALOVÁ L, ZILBERMAN-SCHAPIRA G, MAHDI JA, DAVID E, SAVIDOR A, KOREM T, HERZIG Y, PEVSNER-FISCHER M, SHAPIRO H, CHRIST A, HARMELIN A, HALPERN Z, LATZ E, FLAVELL RA, AMIT I, SEGAL E, ELINAV E. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling[J]. Cell, 2015, 163(6): 1428-1443 DOI:10.1016/j.cell.2015.10.048. [73] TICHO AL, MALHOTRA P, DUDEJA PK, GILL RK, ALREFAI WA. Bile acid receptors and gastrointestinal functions[J]. Liver Research, 2019, 3(1): 31-39 DOI:10.1016/j.livres.2019.01.001. [74] PELUZIO MDCG, MARTINEZ JA, MILAGRO FI. Postbiotics: Metabolites and mechanisms involved in microbiota-host interactions[J]. Trends in Food Science & Technology, 2021, 108: 11-26. [75] CHUDZIK A, ORZYŁOWSKA A, ROLA R, STANISZ GJ. Probiotics, prebiotics and postbiotics on mitigation of depression symptoms: modulation of the brain-gut-microbiome axis[J]. Biomolecules, 2021, 11(7): 1000 DOI:10.3390/biom11071000. [76] WU YP, WANG Y, HU AX, SHU X, HUANG WX, LIU JS, WANG BK, ZHANG RQ, YUE M, YANG CM. Lactobacillus plantarum-derived postbiotics prevent Salmonella-induced neurological dysfunctions by modulating gut-brain axis in mice[J]. Frontiers in Nutrition, 2022, 9: 946096 DOI:10.3389/fnut.2022.946096. [77] LEO A, DE CARO C, MAINARDI P, TALLARICO M, NESCI V, MARASCIO N, STRIANO P, RUSSO E, CONSTANTI A, DE SARRO G, CITRARO R. Increased efficacy of combining prebiotic and postbiotic in mouse models relevant to autism and depression[J]. Neuropharmacology, 2021, 198: 108782 DOI:10.1016/j.neuropharm.2021.108782. [78] AUTERI M, ZIZZO MG, SERIO R. GABA and GABA receptors in the gastrointestinal tract: from motility to inflammation[J]. Pharmacological Research, 2015, 93: 11-21 DOI:10.1016/j.phrs.2014.12.001. [79] YUNES RA, POLUEKTOVA EU, VASILEVA EV, ODORSKAYA MV, MARSOVA MV, KOVALEV GI, DANILENKO VN. A multi-strain potential probiotic formulation of GABA-producing Lactobacillus plantarum 90sk and Bifidobacterium adolescentis 150 with antidepressant effects[J]. Probiotics and Antimicrobial Proteins, 2020, 12(3): 973-979 DOI:10.1007/s12602-019-09601-1.

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