Effects of beta
Review
. 2007;43(8):597-606.
Affiliations
PMID: 17895634Free article
Review
Effects of beta-glucans on the immune system
Dalia Akramiene et al. Medicina (Kaunas). 2007.
Free article
Abstract
Beta-glucans are naturally occurring polysaccharides. These glucose polymers are constituents of the cell wall of certain pathogenic bacteria and fungi. The healing and immunostimulating properties of mushrooms have been known for thousands of years in the Eastern countries. These mushrooms contain biologically active polysaccharides that mostly belong to group of beta-glucans. These substances increase host immune defense by activating complement system, enhancing macrophages and natural killer cell function. The induction of cellular responses by mushroom and other beta-glucans is likely to involve their specific interaction with several cell surface receptors, as complement receptor 3 (CR3; CD11b/CD18), lactosylceramide, selected scavenger receptors, and dectin-1 (betaGR). beta-Glucans also show anticarcinogenic activity. They can prevent oncogenesis due to the protective effect against potent genotoxic carcinogens. As immunostimulating agent, which acts through the activation of macrophages and NK cell cytotoxicity, beta-glucan can inhibit tumor growth in promotion stage too. Anti-angiogenesis can be one of the pathways through which beta-glucans can reduce tumor proliferation, prevent tumor metastasis. beta-Glucan as adjuvant to cancer chemotherapy and radiotherapy demonstrated the positive role in the restoration of hematopiesis following by bone marrow injury. Immunotherapy using monoclonal antibodies is a novel strategy of cancer treatment. These antibodies activate complement system and opsonize tumor cells with iC3b fragment. In contrast to microorganisms, tumor cells, as well as other host cells, lack beta-glucan as a surface component and cannot trigger complement receptor 3-dependent cellular cytotoxicity and initiate tumor-killing activity. This mechanism could be induced in the presence of beta-glucans.
PubMed Disclaimer
LinkOut - more resources
Full Text Sources
Lithuanian University of Health SciencesOther Literature Sources
The Lens - Patent Citations DatabaseMedical
ClinicalTrials.gov MedlinePlus Health InformationResearch Materials
NCI CPTC Antibody Characterization Program相关知识
Fermentation Characteristics and Intestinal Health Effects of Fiber Components
What Are the Negative Effects of Coffee? 15 Effects & Benefits
Electrocardiographic Effects of a Supratherapeutic Dose of WCK 2349, a Benzoquinolizine Fluoroquinolone
The effects of Ramadan intermittent fasting on athletic performance: recommendations for the maintenance of physical fitness
Effects of Academic Stress and Perceived Social Support on the Psychological Wellbeing of Adolescents in Ghana
Resistance training is medicine: effects of strength training on health
Application and effects of health education and management in chronic disease prevention and treatment of elderly in community
Effects of Storage Time and Temperature on the Detection of Cell
How Does University Student’s Academic Stress Affect Their Mental Health Problem? Joint Moderating Effects of Academic Self
Mediating effects of the coping styles between social support and psychological resilience in floating children in Xinjiang Uygur Autonomous Region
网址: Effects of beta https://m.trfsz.com/newsview1897624.html
