茶多酚抗辐射制剂安全毒理学研究
摘要： 为检测茶多酚抗辐射制剂的食用安全性,通过急性毒性试验、遗传毒性试验（Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验）、30d喂养试验进行毒理学研究。结果表明,雌雄两性大、小鼠经口MTD均大于20.0g/kg,Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验3项遗传毒性试验结果均为阴性,显示无致突变性。30d喂养试验（5.00g/kg）未见动物出现中毒症状。试验结果显示,茶多酚抗辐射制剂急性毒性分级属无毒级、无遗传毒性,食用安全性高。
关键词: 茶多酚抗辐射制剂, 急性毒性, 最大耐受量, 遗传毒性, 安全性
Abstract: To evaluate the edible safety of anti-radiation preparations of tea polyphenol, the experiment included acute toxicity test, Ames test, micronucleus test, sperm shape abnormality test and thirty days feeding test were performed. Results showed that the oral maximum tolerance dose(MTD) was higher than 20.0 g/kg·bw both in female and male mice and rats. The results on toxicity of Ames test, micronucleus test, sperm shape abnormality test and mutagencity were negative. No toxicological symptom was appeared in tested animals from thirty days feeding test. It is concluded that the anti-radiation preparations of tea-polyphenol was classified as non-toxicology and genotoxicity, high edible safety.
Key words: anti-radiation preparations of tea-polyphenols, acute toxicity, maximum tolerated dose, genotoxicity, edible safety
中图分类号:
S571.1
R994
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